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Clemson at Louisville - 9/17/15 College Football Pick, Odds, and Prediction

Clemson Tigers (2-0) at Louisville Cardinals (0-2)

College Football: Thursday, September 17, 2015 at 7:30 pm (Papa John's Cardinal Stadium)

The Line: Louisville Cardinals +5.5 -- Over/Under: See the Latest Odds

TV: ESPN

The Clemson Tigers and Louisville Cardinals meet Thursday night at Papa John's Cardinal Stadium.

The Clemson Tigers look to add a big win to their resume and build on their 2-0 start. Deshaun Watson is completing 77.1 percent of his passes for 442 yards, five touchdowns and one interception. Watson has seven touchdown passes in his last three games. Artavis Scott and Charone Peake have combined for more than 240 receiving yards and four touchdowns while freshman Ray-Ray McCloud has nine receptions. The Clemson Tigers ground game is averaging 181 yards per contest, and Wayne Gallman leads the way with 171 yards and three touchdowns. Defensively, Clemson is allowing 10 points and 255.5 yards per game. T.J. Green leads the Tigers with 16 tackles, Shaq Lawson has a sack and Ben Boulware has an interception. Ryan Norton is questionable with a leg injury.

Clemson at Louisville - 9/17/15 College Football Pick, Odds, and Prediction

USA TODAY Sports

The Louisville Cardinals are desperate for a win after a tough 0-2 start to the season. Lamar Jackson is completing 55.3 percent of his passes for 268 yards, one touchdown and three interceptions. Jackson has moved the chains 14 times on 26 completions. Micky Crum and Jaylen Smith have combined for more than 210 receiving yards and one touchdown while senior Ja'Quay Savage has eight receptions. The Louisville Cardinals ground game is averaging 154 yards per contest, and Jackson leads the way with 122 yards and two touchdowns. Defensively, Louisville is allowing 32.5 points and 394.5 yards per game. Josh Harvey-Clemons leads the Cardinals with 24 tackles, Keith Kelsey has two sacks and Chucky Williams has an interception. James Quick, Cole Hikutini, Alphonso Carter and others are questionable with injuries.

The Tigers are 1-4 ATS in their last 5 road games and 4-0 ATS in their last 4 games overall. The Cardinals are 10-3 ATS in their last 13 games following a S.U. loss and 0-6 ATS in their last 6 home games. 

Will the real Louisville Cardinals please stand up? My goodness.

The Cards defense is really struggling out of the gate and the offense is banged up and looking for direction. Meanwhile, Clemson is looking like a real threat in the ACC despite not playing anybody in the first two games. It's hard to back the Cardinals even at home in this spot. I almost have no choice but to take Clemson to cover the touchdown. 

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Clemson Tigers -5.5

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