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Oklahoma State vs. Iowa State - 10/8/16 College Football Pick, Odds, and Prediction

Iowa State Cyclones (1-4) at Oklahoma State Cowboys (2-2)

College Football: Saturday, October 8, 2016 at 3:30 pm (Boone Pickens Stadium)

The Line: Oklahoma State Cowboys -16.5 -- Over/Under: See the Latest Odds

TV: ESPNU

The Iowa State Cyclones and Oklahoma State Cowboys square off Saturday afternoon in a key Big 12 matchup at Boone Pickens Stadium on ESPNU.

The Iowa State Cyclones could use a feel good win that would snap a brutal 12-game losing streak that dates back to the 2014 season. Joel Lanning is completing 60 percent of his passes for 866 yards, seven touchdowns and three interceptions. Lanning has two or more touchdown passes in four of his last seven games. Allen Lazard and Trever Ryen have combined for 537 receiving yards and three touchdowns while Deshaunte Jones has 10 receptions. The Iowa State Cyclones ground game is averaging 141.2 yards per contest, and Mike Warren leads the way with 386 yards and three touchdowns. Defensively, Iowa State is allowing 32.6 points and 452.4 yards per game. Reggan Northrup leads the Cyclones with 38 tackles, Jhaustin Thomas has two sacks and Jomal Wiltz has one interception.

Oklahoma State vs. Iowa State - 10/8/16 College Football Pick, Odds, and Prediction

USA TODAY Sports

The Oklahoma State Cowboys look to put together three straight home victories to remain in the Big 12 race. Mason Rudolph is completing 62.6 percent of his passes for 1,688 yards, nine touchdowns and two interceptions. Rudolph has two or more touchdown passes in five of his last eight games. James Washington and Jalen McCleskey have combined for 912 receiving yards and seven touchdowns while Jhajuan Seales has 18 receptions. The Oklahoma State Cowboys ground game is averaging 134 yards per contest, and Justice Hill leads the way with 346 yards and two touchdowns. Defensively, Oklahoma State is allowing 28.2 points and 447.8 yards per game. Jordan Sterns leads the Cowboys with 39 tackles, Jarrell Owens has two sacks and Ramon Richards has two interceptions.

The Cyclones are 5-0 ATS in their last 5 games after allowing more than 40 points in their previous game. The Cowboys are 0-4 ATS in their last 4 games following a straight up win. The Cyclones are 0-4 ATS in their last 4 meetings in Oklahoma State and the home team is 8-2 ATS in their last 10 meetings.

Iowa State has been a punching bag for Oklahoma State over the years and it's hard seeing this game being any different. The Cyclones had their chance for an upset last week against Baylor and blew it, so it's going to be hard to put that loss behind them and rebound on the road. OK State has loads of offense and is really been flexing its muscle as of late. Oklahoma State has scored no less than 31 points in each of the last seven games against Iowa State.

Have to like the Cowboys blowing out the Cyclones here. 

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Oklahoma State Cowboys -16.5

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