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Giants at Bills - 10/4/15 NFL Pick, Odds, and Prediction

New York Giants (1-2) at Buffalo Bills (2-1)

NFL Football: Sunday, October 4, 2015 at 1:00 pm (Ralph Wilson Stadium)

The Line: Buffalo Bills -6 -- Over/Under: 46.5 See the Latest Odds

TV: FOX

The New York Giants and Buffalo Bills square off Sunday at Ralph Wilson Stadium.

The New York Giants look to get back to a .500 record while also getting their first road win. Eli Manning is completing 64.8 percent of his passes for 764 yards, four touchdowns and zero interceptions. Manning has not thrown a pick in five of his last six games. Odell Beckham Jr. and Rueben Randle have combined for 413 receiving yards and three touchdowns while Shane Vereen has 12 receptions. The New York Giants ground game is averaging 93.3 yards per contest, and Rashad Jennings leads the way with 96 yards and one touchdown. Defensively, New York is allowing 24 points and 410.3 yards per game. Uani' Unga leads the Giants with 26 tackles, Prince Amukamara has four pass deflections and Jonathan Casillas has a sack. Dominique Rodgers-Cromartie, Robert Ayers and Ereck Flowers are questionable.

Giants at Bills - 10/4/15 NFL Pick, Odds, and Prediction

USA TODAY Sports

The Buffalo Bills look to already get their third victory on the season. Tyrod Taylor is completing 74.4 percent of his passes for 714 yards, seven touchdowns and three interceptions. Taylor has thrown for six touchdowns in his last two games. Percy Harvin and Charles Clay have combined for 336 receiving yards and three touchdowns while Robert Woods has nine receptions. The Buffalo Bills ground game is averaging 152.7 yards per contest, and Karlos Williams leads the way with 186 yards and three touchdowns. Defensively, Buffalo is allowing 22.7 points and 400.7 yards per game. Preston Brown leads the Bills with 25 tackles, Ronald Darby has eight pass deflections and Marcell Dareus has a sack. Aaron Williams and Marquise Goodwin are questionable while LeSean McCoy is doubtful.

The Giants are 1-7 ATS vs. a team with a winning record and 5-2 ATS in their last 7 games overall. The Bills are 4-1 ATS in their last 5 home games and 7-19-1 ATS in their last 27 games following a S.U. win. The Giants are 3-1-1 ATS in their last 5 meetings. 

Due to injuries, the Giants are relying way too much on OBJ to bail them out on the offensive side of the ball, something that isn't going to work against Rex Ryan and the Bills. Buffalo's defense is just way too good to get beat by one guy, and the Bills offense is clicking right now.

I'll take the home team and lay the touchdown.

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Buffalo Bills -6

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