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San Diego Chargers vs. San Francisco 49ers - 9/1/16 NFL Pick, Odds, and Prediction

San Francisco 49ers (5-11) at San Diego Chargers (4-12)

NFL Football: Thursday, September 1, 2016 at 10:00 pm (Qualcomm Stadium)

The Line: San Diego Chargers -3.5 -- Over/Under: 40 See the Latest Odds

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The San Francisco 49ers and San Diego Chargers end their preseason Thursday night at Qualcomm Stadium.

The San Francisco 49ers have lost two preseason games by a combined 22 points. In the 21-10 loss to the Green Bay Packers, Jeff Driskel led the way with 43 passing yards on four completions. Driskel and Christian Ponder are sure to get majority of the reps in this game with the starters not playing. Blake Bell and Mike Davis combined for 45 receiving yards on four catches while Garrett Celek had two receptions. The San Francisco 49ers ground game averaged 5.6 yards per carry and Carlos Hyde led the charge with 30 yards on four carries. Defensively, Michael Wilhoite led the 49ers with seven tackles, Will Redmond had one sack and Ray-Ray Armstrong had one pass deflection.

San Diego Chargers vs. San Francisco 49ers - 9/1/16 NFL Pick, Odds, and Prediction

USA TODAY Sports

The San Diego Chargers lost two preseason games by a combined 30 points. In the 23-10 loss to the Minnesota Vikings, Kellen Clemens led the way with 77 passing yards on nine completions. Clemens and Mike Bercovici are sure to get majority of the reps in this game with the starters not playing. Rasheed Bailey and Tyrell Williams combined for 73 receiving yards on five catches while Travis Benjamin had two receptions. The San Diego Chargers ground game averaged four yards per carry and Melvin Gordon led the charge with 51 yards and one touchdown. Defensively, Dexter McCoil led the Chargers with 11 tackles, Ben Gardner had one sack and Kyle Emanuel had one pass deflection.

The 49ers are 6-13 ATS in their last 19 games on grass and 1-5 ATS in their last 6 Thursday games. The Chargers are 1-6 ATS in their last 7 home games and 4-0 ATS in their last 4 games overall. The 49ers are 1-4 ATS in their last 5 meetings. 

The Chargers haven't been great in the preseason and that's with playing their backups for most of those contests. The 49ers have experienced backups and should be able to move the ball. Give me the 49ers and the free points.

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San Francisco 49ers +3.5

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