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San Diego Chargers at Indianapolis Colts - 9/25/16 NFL Pick, Odds, and Prediction

San Diego Chargers (1-1) at Indianapolis Colts (0-2)

NFL Football: Sunday, September 25, 2016 at 4:25 pm (Lucas Oil Stadium)

The Line: Indianapolis Colts -2.5 -- Over/Under: 51.5 See the Latest Odds

TV: CBS

The San Diego Chargers make the trip to Lucas Oil Stadium to take on the winless Indianapolis Colts in week 3 NFL action.

The San Diego Chargers come into this game with a 1-1 record after dismantling the Jacksonville Jaguars 38-14 in week 2.

San Diego Chargers at Indianapolis Colts - 9/25/16 NFL Pick, Odds, and Prediction

USA TODAY Sports

Philip Rivers put on a clinic, completing 17 of 24 passes for 220 yards and 4 touchdowns resulting in a 138.9 passer rating. Melvin Gordon led the way for the Chargers with 102 yards and a touchdown on 24 carries, however a blow was dealt to San Diego’s backfield after they found out they had lost Danny Woodhead for the season after suffering a torn right ACL. Travis Benjamin did his best to fill in for the injured Keenan Allen, hauling in 6 passes for 115 yards and 2 touchdowns. On the defensive side of the ball, Melvin Ingram logged San Diego’s 2 sacks on the afternoon, and forced a fumble that Corey Liuget recovered for the Chargers, and defensive back Casey Heyward logged his first 2 interceptions of the 2016 season off of Blake Bortles.

The Indianapolis Colts fell to 0-2 on the year, falling 34-20 at the hands of the Denver Broncos. Andrew Luck was not able to solve the Denver defense, completing 21 of his 40 pass attempts for 197 yards and a touchdown, which was negated by an Aqib Talib 4th quarter interception return for a touchdown. Frank Gore led the Colts backfield with 44 yards on 13 carries. T.Y. Hilton led the Colts with 4 catches for 41 yards on an otherwise slow day for the Colts offensively, as Indianapolis only managed to gain 253 yards of total offense, the lowest output by any offense in the league in week 2. A sack by defensive lineman Zach Kerr and a Darius Butler interception were the only bright spots in an otherwise mediocre performance from the Colts defense.

San Diego is 7-0 ATS in their last 7 road games and 6-0 ATS in their last 6 vs. the AFC while the over is 12-4-1 in their last 17 against a team with a losing home record. Indianapolis is 2-5 ATS in their last 7 games overall and 0-5 ATS in their last 5 games in September while the over is 5-2 in their last 7 games overall. San Diego is 7-1 ATS in the last 8 meetings between these two teams.

San Diego’s defense is nothing like the Denver Broncos, but I’m not sure Indy has enough to get through them this week. Luck hasn’t looked like himself and the run game looked awful last week. Philip Rivers has yet to throw an interception this year, and if he can avoid throwing one against Indy, I like the Chargers chances to pull off the upset.

Give me San Diego and the points.

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San Diego Chargers +2.5

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