College Football

Alabama vs Southern Miss 9/25/21 College Football Picks, Odds, Predictions

Southern Miss Golden Eagles (1-2) vs. Alabama Crimson Tide (3-0)
September 25, 2021 7:30 pm EDT
The Line: Alabama Crimson Tide -45 / Southern Miss Golden Eagles +45; Over/Under: 55.5
(Get latest betting odds)

The Alabama Crimson Tide meet the Southern Miss Golden Eagles in week 4 college football action from Bryant-Denny Stadium in Tuscaloosa on Saturday night.

The Southern Miss Golden Eagles will have to rebound from a 21-9 loss to Troy in their last game. Trey Lowe and Ty Keyes have each thrown for a touchdown and two interceptions with Lowe throwing for 232 yards on 54.8% passing while Keyes has 207 yards on 52.6% passing. Frank Gore Jr. leads Southern Miss in rushing with 274 rushing yards and a score while Jakarius Caston leads the Golden Eagles in receiving with 7 catches for 88 yards and a touchdown. Defensively, Malik Shorts leads the Golden Eagles with 17 total tackles including a team-high 12 solo tackles while Josh Carr Jr. leads Southern Miss with 2.5 sacks and Eriq Kitchen has a pair of sacks as well this season.

The Alabama Crimson Tide will look to build off of a nail-biting 31-29 win over Florida in their last game. Bryce Young’s thrown for 811 yards and 10 touchdowns on 68% passing while Brian Robinson Jr.’s got a team-high 208 rushing yards and a pair of scores. Jameson Williams leads Bama with 218 receiving yards and a pair of touchdowns while John Metchie III has a team-high 17 grabs for 195 yards. JoJo Earle has 128 receiving yards and Jase McClellan also has a pair of receiving scores as well this season. Defensively, Henry To’o To’o has a team-high 22 total tackles while Phidarian Mathis leads the Tide with 2.5 sacks this season.

Southern Miss is 5-11 ATS in their last 16 games overall and 1-4 ATS in their last 5 games following a double-digit loss at home while the under is 4-0 in their last 4 non-conference games. Alabama is 7-0 ATS in their last 7 games against a team with a losing record and 8-2 ATS in their last 10 home games while the under is 6-1 in their last 7 games against C-USA.

It can be tempting to look at the boatload of points here given that it’s not an FCS opponent Alabama’s got here, but realistically, Southern Miss is in a bad spot here. They just got smothered by Troy and now have to take on an Alabama team that’s being questioned if they’re still the kings of the SEC after a close call against Florida. This is going to be a statement game from Alabama. Lay the points, even though it’s a ton.


Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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