DePaul vs LSU Prediction 11/29/25 College Basketball Picks Today

In this article we will formulate a DePaul vs LSU prediction for this College Basketball game on Saturday, November 29th at Raider Arena in Destin, Florida. Let’s take a look at the prediction for this College Basketball matchup.

DePaul Blue Demons Betting Preview

The DePaul Blue Demons are 5-2 this season after they defeated Georgia Tech by a score of 75-61 in their last game. DePaul trailed 32-25 at halftime, but they scored 50 points in the second half for the comeback win. The Blue Demons shot 48% from the field, 32% on three pointers, and 82% on free throws in the game. Layden Blocker led DePaul with 18 points and four assists, while Brandon Maclin added 16 points and four rebounds in the win. 

Prior to that game, DePaul defeated Detroit Mercy by a score of 95-75 and Gardner-Webb by a score of 93-62. The Blue Demons have scored 80.7 points per game with 37.2 rebounds and 19.5 assists per game, while they have allowed 68.3 points against per game this season. CJ Gunn is averaging 15.8 points and 3.5 rebounds per game, while Layden Blocker is averaging 12.0 points and 4.2 assists per game for the Blue Demons. DePaul is shooting 45.2% from the field, 69.8% on free throws, and 34.7% on three pointers this season. 

LSU Tigers Betting Preview

The LSU Tigers are 6-0 this year after they defeated Drake by a score of 71-62 in their last game. LSU led 38-24 at halftime, but was outscored 38-33 in the second half in the win. The Tigers shot 46% from the field, 26% on three pointers, and 64% on free throws in the game. Dedan Thomas Jr led LSU with 18 points and five assists, while Mike Nwoko added 14 points and eight rebounds in the win. 

Prior to that game, LSU defeated Omaha by a score of 99-73 and Alcorn State by a score of 107-81. The Tigers have scored 98.6 points per game with 44.8 rebounds and 17.6 assists per game, while they have allowed 70.6 points against per game this season. Mike Nwoko is averaging 19.0 points and 5.4 rebounds per game, while Marquel Sutton is averaging 14.4 points and 9.4 rebounds per game for the Tigers. LSU is shooting 54.1% from the field, 79.2% on free throws, and 37.4% on three pointers this year. 

DePaul vs LSU Prediction 

LSU comes into this matchup with a perfect 6-0 record to start the season and they have won their games fairly easily so far. The Tigers are shooting 54% from the field this year and they have scored at least 93 points in four of their last five. DePaul is 5-2 this year, but they have won three games in a row. The Blue Demons are shooting 45% from the field and they have allowed 66 points or fewer in three of their last five. DePaul has played some decent defense, but I think that high scoring LSU offense will drag them into a shootout. Take the over here.