The Duke Blue Devils and Louisville Cardinals meet on Saturday in college basketball action at Spectrum Center. Here’s a Duke vs Louisville prediction. This article will include a Duke vs Louisville Pick.
Louisville Cardinals Betting Preview
The Louisville Cardinals (27-6, 20-13 ATS) have been one of the hottest teams in the country in 2025. They were on a 10-game winning streak before losing to Georgia Tech on the road, but the Cardinals responded with a new, nine-game winning run to secure the No. 2 seed for the ACC tournament. At the tourney, Louisville registered a couple of narrow victories over Stamford and Clemson.
Louisville is averaging 79.1 PPG (59th) and is allowing 68.8 PPG (77th). The Cardinals are getting 37.4 RPG (84th) and dish out 14.1 APG (160th). Chucky Hepburn is the team’s top performer with 16.3 PPG, 3.5 RPG, a team-high 5.9 APG, and a team-high 2.5 SPG. Terrence Edwards Jr. has 16.2 PPG, 4.0 RPG, and 2.6 APG, while Reyne Smith contributes 13.4 PPG and 2.8 RPG.
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Duke Blue Devils Betting Preview
The Duke Blue Devils (30-3, 21-12 ATS) are even in better form than Louisville and are the No. 1 ranked team in the country. Duke won 24 of the last 25 games, and the only loss in this fantastic span came to Clemson, who snapped a 16-game winning streak. The Blue Devils finished 1st in the ACC tournament and defeated Georgia Tech and North Carolina to make it to the conference finals.
Duke averages 83.0 PPG (16th) and allows 61.9 PPG (6th). The Blue Devils are 36th in rebounds (38.7) and 24th in assists (16.9). Cooper Flagg leads the team with 18.9 PPG, 7.5 RPG, 4.1 APG, 1.5 SPG, and 1.3 BPG. Kon Knueppel follows him with 14.2 PPG, 3.9 RPG, 2.7 APG, and 1.0 SPG, while Tyrese Proctor chips in 11.8 PPG, 3.2 RPG, and 2.2 APG.
Why Louisville will cover
- Louisville has won each of its last 13 night games against the Atlantic Coast Conference.
Total Points Facts
- Each of Louisville’s last four night games against the Atlantic Coast Conference has produced a total of 147+ points.
- Each of Duke’s last six Saturday night games against Conference opponents have produced a total of 148+ points.
Matchup/League Facts
- Duke ranks 1st among Division 1 teams for defensive rating this season (92.9).
- Duke ranks 1st among Division 1 teams for net rating this season (+33.5).
- Louisville ranks 26th among Division 1 teams for point differential per game this season (+10.8).
- Louisville ranks 29th among Division 1 teams for opponent free throws made per game this season (10.9).
Duke vs Louisville Prediction
Duke won seven of the previous ten H2H encounters and is on a six-game winning streak over Louisville. The Blue Devils recorded a 76-65 victory this season, but I believe the Cardinals will hand them more trouble in the conference finals. Cooper Flagg is feeling better but will miss out with an ankle injury, which is a chance for the Cardinals to be competitive here. Even without Flagg, Duke has the quality to fend off Louisville and win the title, but I expect a close clash and the Cardinals to cover. Louisville has covered the Spread in 16 of its last 23 games.