Louisville vs Duke Prediction 1/6/26 College Basketball Picks Today

In this article we will formulate a Louisville vs Duke prediction for this College Basketball game on Tuesday, January 6th at the KFC Yum! Center in Louisville, Kentucky. Let’s take a look at the prediction for this College Basketball matchup.

Louisville Cardinals Betting Preview

The Louisville Cardinals are 11-3 (1-1) this season after they lost to Stanford by a score of 80-76 in their last game. Louisville trailed 35-34 at halftime and they allowed 45 points in the second half for the loss. The Cardinals shot 43% from the field, 22% on three pointers, and 86% on free throws in the game. Ryan Conwell led Louisville with 18 points and seven rebounds, while Isaac McKneely added 17 points and three assists in the loss. 

Prior to that game, Louisville defeated Cal by a score of 90-70 and Montana by a score of 94-54. The Cardinals have scored 90.4 points per game with 42.4 rebounds and 18.5 assists per game, while they have allowed 69.1 points against per game this season. Ryan Conwell is averaging 19.6 points and 4.7 rebounds per game, while Isaac McKneely is averaging 11.6 points and 3.1 rebounds per game for the Cardinals. Louisville is shooting 47.1% from the field, 77.5% on free throws, and 35.3% on three pointers this season. 

Duke Blue Devils Betting Preview

The Duke Blue Devils are 13-1 (2-0) this year after they defeated Florida State by a score of 91-87 in their last game. Duke was tied at 42 at halftime, but they scored 49 points in the second half to get the close win. The Blue Devils shot 53% from the field, 44% on three pointers, and 92% on free throws in the game. Isaiah Evans led Duke with 28 points and three rebounds, while Cameron Boozer added 17 points and nine assists in the win. 

Prior to that game, Duke defeated Georgia Tech by a score of 85-79, but lost to Texas Tech by a score of 82-81 before that. The Blue Devils have scored 87.3 points per game with 41.4 rebounds and 18.3 assists per game, while they have allowed 65.5 points against per game this season. Cameron Boozer is averaging 23.0 points and 9.8 rebounds per game, while Isaiah Evans is averaging 13.4 points and 3.4 rebounds per game for the Blue Devils. Duke is shooting 49.8% from the field, 71.6% on free throws, and 35.4% on three pointers this year. 

Why the Louisville Cardinals will win

Why the Duke Blue Devils will win

Total Points Facts

Matchup/League Facts

Louisville vs Duke Prediction 

Duke comes into this matchup after winning two of their last three games, but they really haven’t played well in any of those three games. The Blue Devils are shooting 50% from the field, but their defense has allowed 79+ in three straight. Louisville is coming off of an awful loss to Stanford and they have lost two of their last four. The Cardinals are shooting 47% from the field, but they are missing their second leading scorer. I think Louisville would win if Brown was playing, but I will back Duke on the road, despite their recent form. 

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