Colorado vs Iowa State Prediction Football Picks Today 10/11/25

The Iowa State Cyclones and Colorado Buffaloes meet Saturday in college football action at Folsom Field. Here’s a Colorado vs Iowa State Prediction. This article will include a Colorado vs Iowa State Pick.

Iowa State Cyclones Betting Preview

The Iowa State Cyclones beat Arizona, lost to Cincinnati, and they play BYU next. Iowa State has won 9 of its last 11 games. Rocco Becht is completing 64.9 percent of his passes for 1,417 yards, 9 touchdowns, and 2 interceptions. Brett Eskildsen and Chase Sowell have combined for 557 receiving yards and 3 touchdowns, while Xavier Townsend has 14 receptions.

The Iowa State Cyclones ground game is averaging 151 yards per contest, and Carson Hansen leads the way with 348 yards and 2 touchdowns. Defensively, Iowa State is allowing 14.2 points and 309.6 yards per game. Marcus Neal Jr. leads the Iowa State Cyclones with 39 tackles, Tamatoa McDonough has 2 sacks and Jamison Patton has 2 interceptions.

Colorado Buffaloes Betting Preview

The Colorado Buffaloes lost to BYU and TCU, and they play Utah next. Colorado has won 10 of its last 17 games. Kaidon Salter is completing 65.8 percent of his passes for 901 yards, 7 touchdowns, and 4 interceptions. Omarion Miller and Joseph Williams have combined for 531 receiving yards and 5 touchdowns, while Sincere Brown has 9 receptions.

The Colorado Buffaloes ground game is averaging 143.8 yards per contest, and Micah Welch leads the way with 250 yards and 1 touchdown. Defensively, Colorado is allowing 24.8 points and 398.8 yards per game. Tawfiq Byard leads the Colorado Buffaloes with 40 tackles, Keaten Wade has 2.5 sacks and RJ Johnson has 1 interception.

Why the Colorado Buffaloes will win

Why the Iowa State Cyclones will win

Total Points Facts

Colorado Buffaloes Player Prop Facts

Iowa State Cyclones Player Prop Facts

Matchup/League Facts

Colorado vs Iowa State Prediction

Colorado has been a good home team lately and has had success in the underdog role, but the offense is having issues with turnovers and the defense is heading in the wrong direction. Deion Sanders is also dealing with another medical issue, so who knows if he’ll even be on the sidelines come Saturday.

Iowa State is the better defensive team, has the better quarterback, and has shown it can win away from home. I’d need more points to give the Buffaloes a serious look. I’ll lay the small number with Iowa State on the road.

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