Colorado vs Wyoming Prediction Football Picks Today 9/20/25

The Wyoming Cowboys and Colorado Buffaloes meet Saturday in college football action at Folsom Field. Here’s a Colorado vs Wyoming Prediction. This article will include a Colorado vs Wyoming Pick.

Wyoming Cowboys Betting Preview

The Wyoming Cowboys beat Northern Iowa, lost to Utah and plays UNLV next. Wyoming has split its last 8 games. Kaden Anderson is completing 58.5 percent of his passes for 535 yards, 3 touchdowns, and 2 interceptions. Chris Durr Jr. and John Michael Gyllenborg have combined for 324 receiving yards and 3 touchdowns, while Jackson Holman has 5 receptions.

The Wyoming Cowboys ground game is averaging 158.7 yards per contest, and Sam Scott leads the way with 203 yards and 1 touchdown. Defensively, Wyoming is allowing 12.7 points and 313 yards per game. Andrew Johnson leads the Wyoming Cowboys with 20 tackles, Ben Florentine has 3 sacks and Brayden Johnson has 1 interception.

Colorado Buffaloes Betting Preview

The Colorado Buffaloes lost to Houston, beat Delaware, and they play BYU next. Colorado has won 9 of its last 14 games. Ryan Staub is completing 57.8 percent of his passes for 362 yards, 3 touchdowns, and 2 interceptions. Sincere Brown and Joseph Williams have combined for 252 receiving yards and 2 touchdowns, while Dekalon Taylor has 10 receptions.

The Colorado Buffaloes ground game is averaging 124 yards per contest, and Simeon Price leads the way with 135 yards and 1 touchdown. Defensively, Colorado is allowing 23.3 points and 430 yards per game. Tawfiq Byard leads the Colorado Buffaloes with 19 tackles, Martavius French II has 1 sack and RJ Johnson has 1 interception.

Wyoming Cowboys @ Colorado Buffaloes Betting Trends: Week 4

 

Why the Colorado Buffaloes will win

Why the Wyoming Cowboys will win

Total Points Facts

Colorado Buffaloes Player Prop Facts

Wyoming Cowboys Player Prop Facts

Matchup/League Facts

Colorado vs Wyoming Prediction

Colorado is the more talented team and has been competitive in its two losses, but it still has questions at quarterback and still isn’t great defensively. Colorado is 116th in total defense and 124th in rushing defense. It also doesn’t seem like if the Buffaloes know if they want to roll with Salter or Staub. Colorado is also 3-10-1 ATS in its last 14 games as a double-digit favorite. Wyoming has lots of questions, especially on offense, but that doesn’t mean we just make Colorado a huge favorite. I’ll grab the points with the Cowboys on the road.

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