Duke vs NC State Prediction Football Picks Today 9/20/25

In this article we will formulate a Duke vs NC State prediction for this College Football game on Saturday, September 20th at Wallace Wade Stadium in Durham, North Carolina. Let’s take a look at the prediction for this week 4 matchup. 

Duke Blue Devils Betting Preview

The Duke Blue Devils are 1-2 (0-0) this season after they lost to Tulane by a score of 34-27 last time out. Duke trailed 14-0 after the first quarter and 24-9 at halftime, but they did play better and nearly completed the comeback in the second half. The Blue Devils out gained Tulane by a total of 452-426, went 6-14 on third downs, and tied the turnover battle at one in the game. Darian Mensah went 30-51 for 313 yards, three touchdowns, and one interception, while Nate Sheppard carried the ball five times for 75 yards. Que’Sean Brown led the Duke receivers with six catches for 81 yards in the game. The Duke defense recorded one sack and seven tackles for loss in the defeat. 

Duke started the season with a 45-17 win over Elon in week one, but they lost their game in week two by a score of 45-19 against Illinois. The Blue Devils are averaging 30.3 points per game with 352.7 passing yards and 126.7 rushing yards per game, while they are allowing 32.0 points against per game this season. Darian Mensah has completed 67.2% of his passes for 1,036 yards, eight touchdowns, and two interceptions, while Cooper Barkate has caught 14 passes for 272 yards. Nate Sheppard has led the Duke rushing attack with 127 yards on 15 carries this season. 

NC State Wolfpack Betting Preview

The NC State Wolfpack are 3-0 (1-0) this year after they defeated Wake Forest by a score of 34-24 last week. NC State was tied at 14 after the first quarter and they trailed 24-17 at halftime, but they scored 17 straight in the second half for the win. The Wolfpack out gained Wake by a total of 406-311, went 7-18 on third downs, and won the turnover battle by a margin of 2-0 in the game. CJ Bailey went 23-32 for 201 yards and three touchdowns, while Hollywood Smothers rushed 24 times for 164 yards. Noah Rogers led the NC State receivers with four catches for 52 yards in the game. The NC State defense recorded one sack and three tackles for loss in the victory. 

NC State defeated East Carolina in week one by a score of 24-17 and Virginia in week two by a score of 35-31. The Wolfpack are averaging 31.0 points per game with 239.7 passing yards and 175.3 rushing yards per game, while they are allowing 24.0 points against per game this season. CJ Bailey has completed 70.8% of his passes for 719 yards, five touchdowns, and one interception, while Wesley Grimes has caught nine passes for 173 yards and one score. Hollywood Smothers is the leading rusher with 380 yards and three touchdowns on 63 carries this year. 

Why Duke will beat NC State

Why NC State will beat Duke

Total Points Facts

Matchup/League Facts

David Racey is 16-9 (64%) in his last 25 College Football plays this season. Click here for his premium plays for this week!

Duke vs NC State Prediction 

Duke comes into this matchup as a slight home favorite, but they are looking for their first FBS win of the season. The Blue Devils have had plenty of issues on defense recently, as they have allowed 34 and 45 points in their last two games. On the other side, NC State has scored 34 and 35 points in their last two games, so I am definitely worried about the Duke defense in this contest. I think we will see plenty of scoring from both sides, so take the over here. 

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