Duke vs Virginia Prediction Football Picks Today 12/6/25

In this article, we will formulate a Duke vs Virginia Prediction for this College Football ACC Championship game on Saturday, December 6th. Let’s take a look at the prediction for this College Football matchup.

Virginia Cavaliers Preview

Virginia has a 10-2 record this season and finished 2nd in the ACC. They are coming off a 27-7 home win against Virginia Tech. Offensively, Virginia averages 33.2 points per game, ranking 27th in the nation, while defensively, they allow 20 points per game, which is 24th. Virginia averages 433.2 total yards per game (244.5 passing and 188.7 rushing), while allowing 311.7 total yards per game (108.3 rushing and 203.4 passing).

Chandler Morris leads Virginia with 2,586 passing yards with 65.9% completed passes and 14 touchdowns. Harrison Waylee leads the team in rushing yards with 742, while Trell Harris has a team-high 56 receptions for 809 receiving yards. Defensively, Devin Neal has a team-high 70 total tackles (31 of them solo), while Mitchell Melton leads the team in sacks, with 5, and Kam Robinson and Ja’son Prevard lead the team with 2 interceptions each.

Duke Blue Devils Preview

Duke has a 7-5 record this season and finished 6th in the ACC. They are coming off a 49-32 home win against Wake Forest. Offensively, Duke averages 34.6 points per game, ranking 19th in the nation, while defensively, they allow 29.4 points per game, which is 97th. Duke averages 421.4 total yards per game (289.3 passing and 132.1 rushing), while allowing 414.7 total yards per game (141 rushing and 273.7 passing).

Darian Mensah leads Duke with 3,452 passing yards with 67.5% completed passes and 28 touchdowns. Nate Sheppard leads the team in rushing yards with 786, while Cooper Barkate has a team-high 63 receptions for 978 receiving yards. Defensively, Caleb Weaver has a team-high 79 total tackles (35 of them solo), while Vincent Anthony Jr. leads the team in sacks, with 6.5, and Andrew Pellicciotta has a team-high 2 interceptions.

Duke Blue Devils @ Virginia Cavaliers Betting Trends: Conference Championships

 

Why the Virginia Cavaliers will win

Why the Duke Blue Devils will win

Total Points Facts

Virginia Cavaliers Player Prop Facts

Duke Blue Devils Player Prop Facts

Matchup/League Facts

Duke vs Virginia Prediction

In this Duke vs Virginia Prediction, Virginia is coming as -3.5-point home favorites. Virginia had a better overall record in the regular season and was almost perfect at home, with just one loss in seven games played. They were also very strong against the spread with an 8-4 record, while Duke was just 5-6. Virginia has a superior defense this season, as they allow 9.4 points per game less than Duke and they destroyed Duke in their previous meeting this season by 34-17 on the road. I expect them to repeat that today, so take Virginia and lay the short number at home.

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