Houston vs LSU Prediction Football Picks Today 12/27/25

The LSU Tigers and Houston Cougars meet Saturday in the college football action at NRG Stadium. Here’s a Houston vs LSU Prediction. This article will include a Houston vs LSU Pick.

LSU Tigers Betting Preview

The LSU Tigers beat Western Kentucky and lost to Oklahoma. LSU has lost 5 of its last 8 games. Garrett Nussmeier is completing 67.4 percent of his passes for 1,927 yards, 12 touchdowns, and 5 interceptions. Barion Brown and Zavion Thomas have combined for 968 receiving yards and 5 touchdowns, while Aaron Anderson has 33 receptions.

The LSU Tigers ground game is averaging 106.3 yards per contest, and Caden Durham leads the way with 505 yards and 3 touchdowns. Defensively, LSU is allowing 18.3 points and 319.7 yards per game. A.J. Haulcy leads the LSU Tigers with 89 tackles, Harold Perkins Jr. has 4 sacks and DJ Pickett has 3 interceptions.

Houston Cougars Betting Preview

The Houston Cougars lost to TCU and beat Baylor. The Houston Cougars have won 5 of their last 8 games. Conner Weigman is completing 64 percent of his passes for 2,475 yards, 21 touchdowns, and 9 interceptions. Amare Thomas and Tanner Koziol have combined for 1,557 receiving yards and 15 touchdowns, while Stephon Johnson has 13 receptions.

The Houston Cougars ground game is averaging 175.7 yards per contest, and Dean Connors leads the way with 851 yards and 5 touchdowns. Defensively, Houston is allowing 21.8 points and 348.2 yards per game. Jalen Garner leads the Houston Cougars with 75 tackles, Eddie Walls III has 5.5 sacks and Will James has 3 interceptions.

Why the Houston Cougars will win

Why the LSU Tigers will win

Total Points Facts

Houston Cougars Player Prop Facts

LSU Tigers Player Prop Facts

Matchup/League Facts

Houston vs LSU Prediction

LSU entered this season with goals of a playoff berth, so I question the motivation. This is a home game for Houston, so the crowd presence will be felt. Also, LSU will be missing NFL caliber talent in corner Mansoor Delance, linebacker Harold Perkins Jr., and wide receiver Aaron Anderson. Outside of offensive lineman Demetrius Hunter, everybody is suiting up for Houston.

LSU was 4-8 ATS on the season, while Houston was 8-4 ATS. Since September, LSU is 0-5 SU and 1-4 ATS as an underdog. LSU has lost those games by an average of 10.2 points. Short line, I’m going to side with Houston.

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