Iowa State vs Kansas Prediction Football Picks Today 11/22/25

The Kansas Jayhawks and the Iowa State Cyclones meet in week 13 college football action from Jack Trice Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Iowa State vs Kansas Prediction.

Kansas Jayhawks Recap

The Kansas Jayhawks come into this game looking to bounce back from a 24-20 loss at the hands of the Arizona Wildcats last time out to sit at 5-5 this season. After this game, Kansas will head home to close out the regular season against Utah.

Jayhawks Drop 3 Of Last 4

Jalon Daniels has thrown for 2,190 yards, 21 touchdowns and 3 interceptions on 65.1% passing while also rushing for 345 yards and 3 scores. Daniel Hishaw Jr. leads Kansas in rushing with 430 yards and 4 TDs while Leshon Williams has 414 rushing yards and 6 TDs as well this season. Emmanuel Henderson Jr. has a team-high 41 catches for 638 yards and 5 touchdowns while Boden Groen has 374 receiving yards and 4 TDs and Cam Pickett has 423 receiving yards and 3 TDs. Three more Jayhawks have 100+ receiving yards as well this season. On defense, Trey Lathan has a team-high 69 total tackles including 1.5 sacks while Leroy Harris III has a team-high 4.5 sacks. As a unit, Kansas’ defense has combined for 24 sacks and 4 interceptions so far this season.

Why the Kansas Jayhawks will win

Iowa State Cyclones Recap

The Iowa State Cyclones come into this game looking to build on their 20-17 win over TCU last time out to sit at 6-4 this season. After this game, Iowa State will head on the road to close out the regular season against Oklahoma State.

Cyclones Snap Four-Game Slide

Rocco Becht has thrown for 2,230 yards, 12 touchdowns and 9 interceptions on 59.9% passing while Carson Hansen leads the Cyclones in rushing with 721 yards and 5 touchdwons and Abu Sama III has 588 yards and 4 TDs as well on the year. Brett Eskildsen leads Iowa State in receiving with 434 receiving yards in addition to 3 TDs while Benjamin Brahmer has 33 grabs for 388 yards and 5 touchdowns and Chase Sowell has 26 catches for 386 yards and a TD. Gabe Burkle has 26 catches for 302 yards and a touchdown as well on the year. On defense, Marcus Neal Jr. has a team-high 70 total tackles while Iowa State’s defense as a unit has combined for 10 sacks and 9 interceptions so far this season.

Why the Iowa State Cyclones will win

Total Points Facts

Iowa State vs Kansas Prediction

I’m on Kansas and the points here. I get why Iowa State’s favored at home on Senior day, but the Cyclones already have a bowl game locked up. While no team will say they’re going to lose against another team, I think Kansas would view this as a much more winnable spot than to try to knock off a Utah team. They’re aiming for style points for a college football playoff spot next week. Even at home. The Cyclones haven’t been all that impressive this season, and I still believe that Kansas is the better team here. Give me the Jayhawks and the points in a game I think Kansas can win outright.

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