Iowa vs USC Prediction 11/15/25 College Football Picks Today

In this article, we will formulate a Iowa vs USC Prediction for this College Football Week 12 game on Saturday, November 15th. Let’s take a look at the prediction for this College Football matchup.

USC Trojans Preview

USC has a 7-2 record this season and is sitting 3rd in the Big Ten. They are 5-4 ATS, 5-4 in Over/Under and have a 5-0 home record and a 2-2 away record. USC is coming off a 38-17 home win against Northwestern and will face Iowa and Oregon next.

Offensively, USC averages 39.6 points per game, ranking 7th in the nation, while defensively, they allow 21.8 points per game, which is 45th. USC averages 503.2 total yards per game (303.0 passing and 200.2 rushing), while allowing 346.8 total yards per game (141.7 rushing and 205.1 passing).

Jayden Maiava leads USC with 2,614 passing yards with 66.2% completed passes and 17 touchdowns. King Miller leads the team in rushing yards with 636, while Makai Lemon has a team-high 61 receptions for 937 receiving yards. Defensively, Eric Gentry has a team-high 61 total tackles (44 of them solo), while Kameryn Crawford leads the team in sacks, with 3.5, and Bishop Fitzgerald has a team-high 5 interceptions.

Iowa Hawkeyes Preview

Iowa has a 6-3 record this season and is sitting 6th in the Big Ten. They are 6-2-1 ATS, 4-4-1 in Over/Under and have a 4-2 home record and a 2-1 away record. Iowa is coming off a 16-18 home loss against Oregon and will face USC, Michigan State and Nebraska next.

Offensively, Iowa averages 29.6 points per game, ranking 61st in the nation, while defensively, they allow 13.7 points per game, which is 5th. Iowa averages 309.1 total yards per game (133.2 passing and 175.9 rushing), while allowing 250.2 total yards per game (103.6 rushing and 146.7 passing).

Mark Gronowski leads Iowa with 1,084 passing yards with 63.9% completed passes and 5 touchdowns. Kamari Moulton leads the team in rushing yards with 522, while Sam Phillips has a team-high 13 receptions for 216 receiving yards. Defensively, Karson Sharar has a team-high 56 total tackles (24 of them solo), while Max Llewellyn leads the team in sacks, with 6, and Zach Lutmer has a team-high 2 interceptions.

Iowa Hawkeyes @ USC Trojans Betting Trends: Week 12

 

Why the USC Trojans will win

Why the Iowa Hawkeyes will win

Total Points Facts

USC Trojans Player Prop Facts

Iowa Hawkeyes Player Prop Facts

Matchup/League Facts

Iowa vs USC Prediction

In this Iowa vs USC Prediction, USC is coming as -6.5-point home favorites, with the total set at 49.5 points. Both teams have been very good this season and are both coming into this matchup in very good form. USC is 3-1 in its last 4 games and have been undefeated in their five home games, while Iowa is 5-2 in its last 7 games and 6-1 against the spread. USV has the 6th-best offense in the country and are going up against Iowa’s 5th-best defense, so I expect a hard-fought battle and a tight game. Take Iowa to keep this one close and get the +6.5 points.

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