Louisville vs Virginia Prediction Football Picks Today 10/4/25

The Virginia Cavaliers and the Louisville Cardinals meet in week 6 college football action from L&N Federal Credit Union Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Virginia Cavaliers vs. Louisville Cardinals prediction.

Virginia Cavaliers Recap

The Virginia Cavaliers come into this game looking to build on their 46-38 upset win over Florida State last time out to improve to 4-1 this season. After this game, Virginia will have a bye before taking on Washington State at home.

Cavaliers Win Three Straight After Upset Of Seminoles

Chandler Morris has thrown for 1,279 yards, 10 touchdowns and 4 interceptions on 71.6% passing along with 169 rushing yards and 4 TDs on the ground while J’Mari Taylor has rushed for a team-high 397 yards and 7 touchdowns so far this season to lead Virginia on the ground. Harrison Waylee has 229 rushing yards with 4 touchdowns while Xavier Brown has 206 rushing yards and a TD. Trell Harris leads the Cavaliers with 366 receiving yards and 3 TDs on 21 catches while Cam Ross has a team-high 24 grabs for 286 yards and a touchdown. Jahmal Edrine also has 214 receiving yards with a TD while two more Cavaliers have 100+ receiving yards as well this season. On defense, Devin Neal has a team-high 26 total tackles while Daniel Rickert has a team-high 3.5 sacks this season. As a unit, Virginia has combined for 11 sacks and 3 interceptions so far this season. 

Why the Virginia Cavaliers will win

Louisville Cardinals Recap

The Louisville Cardinals come into this game looking to build on their 34-27 win over Pitt last time out to improve to 4-0 this season. After this game, Louisville will head on the road for a game against the Miami Hurricanes following a bye week.

Cardinals Looking To Stay Undefeated

Miller Moss has thrown for 1,029 yards, 5 touchdowns and 3 interceptions on 65.6% passing while Isaac Brown leads Louisville in rushing with 268 rushing yards and 3 touchdowns and Keyjuan Brown has 110 rushing yards and 3 TDs as well. Chris Bell leads Louisville with 23 grabs for 332 receiving yards and 2 touchdowns while Caullin Lacy has 22 catches for 266 yards this season. Two more Louisville receivers have 100+ receiving yards as well this season. On defense, TJ Quinn has a team-high 22 total tackles and 2 interceptions while Clev Lubin has a team-high 3.5 sacks. As a unit, Louisville’s defense has combined for 12 sacks and 6 interceptions so far this season.

Why the Louisville Cardinals will win

Total Points Facts

Virginia Cavaliers vs. Louisville Cardinals Prediction

I’m on Virginia and the points here. I just think these are two teams that are fairly evenly matched and Chandler Morris looks like quite the pickup for Virginia. I think this is going to be a game that comes down to the wire, and could be a game decided on the final possession. Give me the points with Virginia.

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