Notre Dame vs Syracuse Prediction Football Picks Today 11/22/25

The Syracuse Orange and Notre Dame Fighting Irish meet Saturday in college football action at Notre Dame Stadium. Here’s a Notre Dame vs Syracuse Prediction. This article will include a Notre Dame vs Syracuse Pick.

Syracuse Orange Betting Preview

The Syracuse Orange lost to North Carolina and Miami, and plays Boston College next. Syracuse has lost 6 straight games. Steve Angeli is completing 62.8 percent of his passes for 1,317 yards, 10 touchdowns and 2 interceptions. Johntay Cook and Darrell Gill Jr. have combined for 995 receiving yards and 7 touchdowns, while Dan Villari has 33 receptions.

The Syracuse Orange ground game is averaging 117.7 yards per contest, and Yasin Willis leads the way with 558 yards and 4 touchdowns. Defensively, Syracuse is allowing 31.5 points and 430.6 yards per game. Gary Bryant III leads the Syracuse Orange with 50 tackles, Kevin Jobity Jr. has 5 sacks, and Davien Kerr has 3 interceptions.

Notre Dame Fighting Irish Betting Preview

The Notre Dame Fighting Irish beat Pitt and Navy, and play Stanford next. The Notre Dame Fighting Irish have won 8 straight games. CJ Carr is completing 67.3 percent of his passes for 2,487 yards, 21 touchdowns, and 6 interceptions. Jordan Faison and Malachi Fields have combined for 1,147 receiving yards and 8 touchdowns, while Eli Raridon has 30 receptions.

The Notre Dame Fighting Irish ground game is averaging 192.5 yards per contest, and Jeremiyah Love leads the way with 1,135 yards and 14 touchdowns. Defensively, Notre Dame is allowing 18.4 points and 323.3 yards per game. Drayk Bowen leads the Notre Dame Fighting Irish with 57 tackles, Boubacar Traore has 6.5 sacks and Tae Johnson has 4 interceptions.

Why the Notre Dame Fighting Irish will win

Why the Syracuse Orange will win

Total Points Facts

Notre Dame Fighting Irish Player Prop Facts

Syracuse Orange Player Prop Facts

Matchup/League Facts

Notre Dame vs Syracuse Prediction

Neither Notre Dame nor Syracuse are covering numbers this season, so seeing a line this thick is a bit stunning. However, Notre Dame has covered 10 of its last 14 games as a double-digit favorite. In the 7 games this season, Notre Dame has been a double-digit favorite, it’s winning by an average of 23.1 points.

Syracuse has nothing to scare Notre Dame, as its 108th in scoring offense and 117th in scoring defense. This could be a win and get out situation for Notre Dame, as it’s closing in on a playoff spot, but Syracuse is that bad. Notre Dame should win this game by a crime scene margin.

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