Oklahoma vs Michigan Prediction Football Picks Today 9/6/25

The Michigan Wolverines and the Oklahoma Sooners meet in week 2 college football action from Memorial Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Michigan Wolverines vs. Oklahoma Sooners prediction.

Michigan Wolverines Recap

The Michigan Wolverines come into this game looking to build on their season-opening 34-17 win over New Mexico last time out to improve to 1-0 this season. After this game, the Wolverines will head home for a game against Central Michigan.

Wolverines Looking To Pick Up Marquee Road Win

Bryce Underwood threw for 251 yards and a touchdown on 21 of 31 passing while Justice Haynes rushed for 159 yards and 3 TDs on 16 carries. Marlin Klein led the Wolverines in receiving with 6 grabs for 93 yards and a touchdown while Channing Goodwin had 49 receiving yards as well in the win. On defense, Ernest Hausmann led the Wolverines with 8 total tackles including 5 solo tackles while Cole Sullivan added a sack and Troy Bowles chipped in a sack as well as Dominic Nichols. TJ Guy, Brandyn Hillman and the aforementioned Sullivan all contributed an interception for the Wolverines as well in the victory.

Why the Michigan Wolverines will win

Oklahoma Sooners Recap

The Oklahoma Sooners come into this game looking to build on their 35-3 win over Illinois State to start the year 1-0. After this game, Oklahoma will head on the road for a game against the Temple Owls.

Sooners Looking To Defend Home Turf

John Mateer threw for 392 yards, 3 touchdowns and an INT on 30 of 37 passing while Tory Blaylock led the Sooners on the ground with 44 rushing yards and a touchdown and Mateer also added 24 rushing yards and a touchdown as well. Keontez Lewis chipped in 9 grabs for 119 yards and 2 touchdowns while Jaren Kanak had 5 receptions for 90 receiving yards and Deion Burks added 7 grabs for 88 yards and a touchdown in the win. On defense, Sammy Omosigho had a team-high 8 total tackles including a sack while Taylor Wein also had a sack for the Sooners in the win. 

Why the Oklahoma Sooners will win

Total Points Facts

Michigan Wolverines vs. Oklahoma Sooners Prediction

I’m on Oklahoma here. I get the case to be made for Michigan as this line went crazy during the week and could be viewed as an overreaction to week one. However, what I still see is a young QB in Bryce Underwood making a road start in SEC country, and the Sooners, while they had issues getting their offense going in week one against Illinois State, I still think there’s a lot to like about this team going forward and I think they get the job done at home by a touchdown here. Give me Oklahoma.

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