Oklahoma vs Ole Miss Prediction Football Picks Today 10/25/25

The Ole Miss Rebels and Oklahoma Sooners meet Saturday in college football action at Memorial Stadium. Here’s a Oklahoma vs Ole Miss Prediction. This article will include a Oklahoma vs Ole Miss Pick.

Ole Miss Rebels Betting Preview

The Ole Miss Rebels beat Washington State, lost to Georgia, and they play South Carolina next. The Ole Miss Rebels have won 8 of their last 9 games. Trinidad Chambliss is completing 62.7 percent of his passes for 1,549 yards, 8 touchdowns, and 1 interception. Harrison Wallace III and Dae’Quan Wright have combined for 793 receiving yards and 5 touchdowns, while Deuce Alexander has 22 receptions.

The Ole Miss Rebels ground game is averaging 187.7 yards per contest, and Kewan Lacy leads the way with 618 yards and 10 touchdowns. Defensively, Ole Miss is allowing 22.6 points and 362.3 yards per game. TJ Dottery leads the Ole Miss Rebels with 46 tackles, Will Echoles has 3 sacks and Wydett Williams Jr. has 1 interception.

Oklahoma Sooners Betting Preview

The Oklahoma Sooners lost to Texas, beat South Carolina, and play Tennessee next. Oklahoma has won 6 of its last 7 games. John Mateer is completing 64.9 percent of his passes for 1,567 yards, 7 touchdowns, and 6 interceptions. Isaiah Sategna III and Jaren Kanak have combined for 857 receiving yards and 4 touchdowns, while Deion Burks has 32 receptions.

The Oklahoma Sooners ground game is averaging 122.3 yards per contest, and Tory Blaylock leads the way with 391 yards and 4 touchdowns. Defensively, Oklahoma is allowing 9.8 points and 211.2 yards per game. Kip Lewis leads the Oklahoma Sooners with 31 tackles, R Mason Thomas has 5.5 sacks and Taylor Wein has 1 interception.

Why the Oklahoma Sooners will win

Why the Ole Miss Rebels will win

Total Points Facts

Oklahoma Sooners Player Prop Facts

Ole Miss Rebels Player Prop Facts

Matchup/League Facts

Oklahoma vs Ole Miss Prediction

Oklahoma is going to get the benefit of the doubt with that elite defense and being at home. However, Mateer hasn’t been the same quarterback in his first two games back from hand surgery. Ole Miss is also an elite level offense that will test this Sooners defense. Ole Miss made Georgia look silly last week and probably should’ve won that game outright if we’re being honest.

Ole Miss has covered 6 of its last 9 games as an underdog, and 5 of those covers were outright victories. Oklahoma has also had issues running the ball, which would play into the strength of this Rebels defense if forced to pass. Give me the points in what should be a fun SEC back and forth.

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