In this article we will formulate an Ole Miss vs Charlotte prediction for this College Football game on Saturday, September 12th at Vaught-Hemingway Stadium in Oxford, Mississippi. Let’s take a look at the prediction for this Week 2 matchup.
Ole Miss Rebels Betting Preview
The Ole Miss Rebels are 1-0 this season after they defeated Louisville by a score of 41-38 in week one. Ole Miss led 10-6 at halftime, but the second half turned very high scoring, before they escaped with a winning field goal. The Rebels out gained Louisville by a total of 488-469, went 6-16 on third downs, and lost the turnover battle by a total of 2-0 in the game. Trinidad Chambliss threw for 336 yards, three touchdowns, and one interception, while Deuce Alexander caught five passes for 159 yards and two scores. Kewan Lacy rushed 17 times for 61 yards and one touchdown in the win.
Last season, Ole Miss went 13-2 (7-1) and they finished tied for first in the SEC standings. The Rebels started the year with a 63-7 win over Georgia State and followed that up with a 30-23 win over Kentucky. Ole Miss only lost to Georgia in the regular season, before defeating Tulane 41-10, defeating Georgia 39-34, and losing to Miami 31-27 in the College Football Playoff.
Charlotte 49ers Betting Preview
The Charlotte 49ers are 0-1 this year after they lost to The Citadel by a score of 43-41 in triple overtime. Charlotte led 14-7 at halftime, but they needed a score with 24 seconds left in regulation to tie the game, before they lost in triple OT. The 49ers out gained their opponent by a total of 538-400, went 11-17 on third downs, and lost the turnover battle by a total of 2-0 in the game. Cole Gonzales threw for 322 yards, three touchdowns, and two interceptions, while Jaylen Hampton caught eight passes for 117 yards and two scores. Khamani Alexander rushed 14 times for138 yards and one touchdown in the loss.
The 49ers went 1-11 (0-8) last year and they finished last in the American Conference standings. Charlotte started the season with a 34-11 loss to App State, which was followed up by a 20-3 loss to UNC. The 49ers did defeat Monmouth by a score of 42-35 in week three, but they lost each of the last nine games. Charlotte really struggled offensively, as they scored 20 points or fewer in six of their last seven games, while they allowed 27+ points in 10 of their last 12 games. The 49ers scored 14.3 points per game in 2025, while they allowed 36.3 points against per game on defense.
Why the Ole Miss Rebels will win
- Ole Miss has won each of its last 18 games against non-conference opponents at Vaught-Hemingway Stadium.
- Charlotte has lost each of its last 10 games.
- Ole Miss has covered the spread in eight of its last nine September games at Vaught-Hemingway Stadium.
- Charlotte has failed to cover the spread in three of its last four games in September.
- Ole Miss has won the first half in each of its last 18 games against non-conference opponents at Vaught-Hemingway Stadium.
- Ole Miss has won the first quarter in 11 of its last 12 games as a top-10 AP-ranked team at Vaught-Hemingway Stadium.
Why the Charlotte 49ers will win
- The road team has covered the spread in each of Charlotte’s last eight games.
- Ole Miss has failed to cover the spread in four of its last five games against non-conference opponents.
Total Points Facts
- Seven of Ole Miss’ last eight games in Mississippi have gone UNDER the total points line.
- Each of Charlotte’s last three road openers have gone OVER the total points line.
Ole Miss Rebels Player Prop Facts
- Trinidad Chambliss has recorded 275+ passing yards in seven consecutive games – longest streak in the FBS, heading into Week 2.
Charlotte 49ers Player Prop Facts
- Heading into Week 2, Jason Jeffares ranks T1st amongst qualified players for catch rate (100.0%) this season.
Matchup/League Facts
- One of Ole Miss’ one games this season have been decided by a margin of seven points or less – equal-most amongst FBS teams.
- One of Ole Miss’ one games this season have been decided by a margin of three points or less – equal-most amongst FBS teams.
- Charlotte ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).
- Charlotte ranks 129th among FBS teams for rushing yards allowed per game this season (268.0).
Ole Miss vs Charlotte Prediction
Ole Miss comes into this matchup as a huge favorite to get the win after barely surviving against Louisville last week. The Rebels should win this game very easily, but they do have LSU on deck. Charlotte lost to The Citadel in week one, which was one of the worst losses of the week. The 49ers moved the ball well, but their defense was way too soft. I would be shocked if this game is remotely close, but I will take the points with Charlotte, as Ole Miss is probably focused on LSU.