SMU vs Clemson Prediction 10/18/25 College Football Picks Today

In this article, we will formulate a SMU vs Clemson Prediction for this College Football Week 8 game on Saturday, October 18th at the Memorial Stadium (Clemson, SC). Let’s take a look at the prediction for this College Football matchup.

Clemson Tigers Preview

Clemson has a 3-3-0 record this season and is sitting 7th in the ACC. They are 2-4-0 ATS, 2-4-0 in Over/Under and have a 1-2-0 home record and a 2-1-0 away record. Clemson is coming off a 41-10 road win against Boston College and will face Duke, Florida State and Louisville next.


Offensively, Clemson averages 26.3 points per game, ranking 82nd in the nation, while defensively, they allow 18.5 points per game, which is 28th. Clemson averages 408.8 total yards per game (278.8 passing and 130 rushing), while allowing 322.3 total yards per game (104.8 rushing and 217.5 passing).

Cade Klubnik leads Clemson with 1,530 passing yards with 65.8% completed passes and 11 touchdowns. Adam Randall leads the team in rushing yards with 404, while Bryant Wesco Jr. has a team-high 31 receptions for 537 receiving yards. Defensively, Ronan Hanafin, Sammy Brown and Wade Woodaz are tied for the team-high with 39 total tackles, while Will Heldt leads the team in sacks, with 3.5, and Ricardo Jones has a team-high 2 interceptions.

SMU Mustangs Preview

SMU has a 4-2-0 record this season and is sitting 4th in the ACC. They are 1-5-0 ATS, 1-5-0 in Over/Under and have a 3-1-0 home record and a 1-1-0 away record. SMU is coming off a 34-10 home win against Stanford and will face Wake Forest, Miami (FL) and Boston College next.

Offensively, SMU averages 34 points per game, ranking 43rd in the nation, while defensively, they allow 22.3 points per game, which is 55th. SMU averages 404.8 total yards per game (277.8 passing and 127 rushing), while allowing 423.2 total yards per game (107.3 rushing and 315.8 passing).

Kevin Jennings leads SMU with 1,658 passing yards with 71.7% completed passes and 15 touchdowns. TJ Harden leads the team in rushing yards with 415, while Romello Brinson has a team-high 32 receptions for 484 receiving yards. Defensively, Isaiah Nwokobia has a team-high 48 total tackles (26 of them solo), while Cam Robertson leads the team in sacks, with 4.5, and Ahmaad Moses has a team-high two interceptions.

SMU Mustangs @ Clemson Tigers Betting Trends: Week 8

 

Why the Clemson Tigers will win

Why the SMU Mustangs will win

Total Points Facts

Clemson Tigers Player Prop Facts

SMU Mustangs Player Prop Facts

Matchup/League Facts

SMU vs Clemson Prediction

In their previous meeting last season, Clemson won 34-31 on the road. In this SMU vs Clemson Prediction, Clemson is coming as -9.5-point home favorites, with the total set at 55.5 points. Both teams have back-to-back wins, but SMU has trouble covering spreads, as they are just 1-5 ATS this season. Both teams are also playing amazing defense lately, having held their opponents into just 10 and 14 points per game across their last two games respectively. I expect both defenses to shine once again, so take the under 55.5 in this one.

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