SMU vs Louisville Prediction Football Picks Today 9/19/26

In this article, we will formulate a SMU vs Louisville Prediction for this College Football Week 3 matchup on Saturday, September 19th. Let’s take a look at the prediction for this College Football matchup.

Louisville Cardinals Preview

Louisville has a 1-1 record this season and are coming off a 59-13 home win against Villanova. They will face Wake Forest and NC State next. Offensively, Louisville averages 48.5 points per game, ranking 17th in the nation, while defensively, they allow 27 points per game, which is 102nd. Louisville averages 552 total yards per game (341 passing and 211 rushing), while allowing 370.5 total yards per game (113.5 rushing and 257 passing).

Lincoln Kienholz leads Louisville with 639 passing yards with 68% completed passes and 4 touchdowns. Isaac Brown leads the team in rushing yards with 97, while Tre Richardson has a team-high 11 receptions for 181 receiving yards. Defensively, Koen Entringer has a team-high 12 total tackles (7 of them solo), while Tyler Thompson leads the team with one sack.

SMU Mustangs Preview

SMU has a 2-0 record this season and are coming off a 56-10 home win against UC Davis. They will face Missouri State and Boston College next. Offensively, SMU averages 41.5 points per game, ranking 32nd in the nation, while defensively, they allow 17 points per game, which is 54th. SMU averages 566 total yards per game (442 passing and 124 rushing), while allowing 278.5 total yards per game (130.5 rushing and 148 passing).

Kevin Jennings leads SMU with 767 passing yards with 76.9% completed passes and 8 touchdowns. Kendrick Raphael leads the team in rushing yards with 78, while Yannick Smith has a team-high 6 receptions for 151 receiving yards. Defensively, Jimmy Wyrick has a team-high 11 total tackles (5 of them solo), leading the team with 2 sacks.

SMU Mustangs @ Louisville Cardinals Betting Trends: Week 3

 

Why the Louisville Cardinals will win

Why the SMU Mustangs will win

Total Points Facts

Louisville Cardinals Player Prop Facts

SMU Mustangs Player Prop Facts

Matchup/League Facts

SMU vs Louisville Prediction

In this SMU vs Louisville Prediction, Louisville is coming as -1.5 home favorites. Both teams are coming off big wins in the previous week, with Louisville winning by 36 points at home and SMU by 46 on the road. Both teams have been on fire offensively, scoring 90 points per game combined and as a result, their last three games combined have gone over the total. While this offensive production is unsustainable, the Cardinals rank outside the top-100 of the country defensively, so I expect a high-scoring affair. Take the over 59.5 points in this one.

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