SMU vs Louisville Prediction Football Picks Today 11/22/25

The Louisville Cardinals and the SMU Mustangs meet in week 13 college football action from Gerald J. Ford Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a SMU vs Louisville Prediction.

Louisville Cardinals Recap

The Louisville Cardinals come into this game looking to bounce back from a 20-19 loss at the hands of Clemson last time out to sit at 7-3 this season. After this game, Louisville will head home for a rivalry matchup against Kentucky.

Cardinals Drop Back-To-Back Games

Miller Moss leads Louisville in passing with 2,344 yards, 11 touchdowns and 7 interceptions on 64.3% passing while Isaac Brown has a team-high 782 rushing yards and 5 touchdowns and Keyjuan Brown has 592 rushing yards with 6 TDs. Chris Bell leads Louisville’s receiving group with 67 grabs for 871 yards and 6 touchdowns while Caullin Lacy has 52 catches for 542 yards and 2 TDs. On defense, TJ Quinn has a team-high 72 total tackles while Antonio Watts has a team-high 3 INTs and Clev Lubin and Wesley Bailey each have 5 sacks. As a unit, Louisville’s defense has combined for 20 sacks and 12 interceptions so far this season.

Why the Louisville Cardinals will win

SMU Mustangs Recap

The SMU Mustangs come into this game looking to build on their 45-13 win over Boston College last time out to sit at 7-3 this season. After this game, SMU will head on the road for a game against Cal to close out the regular season. 

Mustangs Win 5 Of Last 6

Kevin Jennings has thrown for 2,810 yards, 21 touchdowns and 9 interceptions on 64.8% passing while T.J. Harden leads SMU in rushing with 613 yards and 6 touchdowns. Chris Johnson Jr. also has 316 rushing yards and 3 TDs on the ground while Jordan Hudson has a team-high 42 receptions for 595 yards and 4 TDs. Romello Brinson has 582 receiving yards on 40 grabs with 3 TDs and Yamir Knight’s added 460 receiving yards with 4 TDs. Three more Mustangs have 200+ receiving yards as well this season. On defense, Isaiah Nwokobia leads the Mustangs with 77 total tackles including 40 solo tackles while Isaiah Smith has a team-high 8 sacks and Ahmaad Moses has a team-high 5 interceptions. Terry Webb and Jeffrey M’Ba each have 5.5 sacks and Cameron Robertson has 5 sacks this season. As a unit, SMU’s defense has combined for 33 sacks and 16 interceptions so far this season.

Why the SMU Mustangs will win

Total Points Facts

SMU vs Louisville Prediction

I’m on SMU here. I just think that home field is going to be the difference here between two teams with little to play for except pride at this point. Both have clinched a bowl game and neither is going to the ACC title game. I look for SMU to keep up their home momentum and to win this one by a TD so give me SMU here. 

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