Syracuse vs Louisville Prediction Football Picks Today 10/17/26

In this article we will formulate a Syracuse vs Louisville prediction for this College Football game on Saturday, October 17th at the JMA Wireless Dome in Syracuse, New York. Let’s take a look at the prediction for this Week 7 matchup. 

Syracuse Orange Betting Preview

The Syracuse Orange are 2-3 (0-3) this season after they lost to Virginia by a score of 28-25 in their last game. Syracuse led 17-7 at halftime, but they allowed the first 21 points in the second half and couldn’t recover in the loss. The Orange out gained UVA by a total of 430-282, went 5-15 on third downs, and tied the turnover battle at zero in the game. Malachi Nelson threw for 217 yards and one touchdown, while Umari Hatcher caught eight passes for 126 yards and one score. Tylik Hill rushed 23 times for 118 yards in the loss. 

Prior to that game, Syracuse defeated UConn by a score of 42-41, but lost to Pittsburgh by a score of 27-13 before that. The Orange have scored 32.8 points per game with 281.6 passing yards and 165.8 rushing yards per game, while they have allowed 24.0 points against per game this season. Syracuse is dealing with injuries to their top three quarterbacks, so we will see how is healthy enough to start this one. 

Louisville Cardinals Betting Preview

The Louisville Cardinals are 3-3 (2-2) this year after they defeated Florida State by a score of 44-20 in their last game. Louisville was tied 14-14 at halftime and they scored 30 points in the second half for the lopsided win. The Cardinals out gained FSU by a total of 537-362, went 4-9 on third downs, and won the turnover battle by a total of 1-0 in the game. Lincoln Kienholz threw for 140 yards, while Lawayne McCory caught three passes for 78 yards. Isaac Brown rushed 17 times for 235 yards and two scores in the game. 

Prior to that win, Louisville lost to NC State by a score of 31-28 and Wake Forest by a score of 30-27. The Cardinals have scored 39.5 points per game with 262.8 passing yards and 231.7 rushing yards per game, while they have allowed 27.7 points against per game this season. Lincoln Kienholz has thrown for 1,534 yards with nine touchdowns and one interception this year. 

Why the Virginia Tech Hokies will win

Why the Georgia Tech Yellow Jackets will win

Total Points Facts

Virginia Tech Hokies Player Prop Facts

Georgia Tech Yellow Jackets Player Prop Facts

Matchup/League Facts

Syracuse vs Louisville Prediction 

Syracuse comes into this matchup after losing three of their last four games, but all three losses were by 14 points or less. Louisville has lost two of their last three games and they have allowed 30+ points in three of their last four. The Cardinals have been disappointing so far this year, but Brown is one of the best running backs in the country. I would love to take the points here, but I have no idea what the plan is at QB for the Orange. Take Louisville to cover here. 

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