Syracuse vs SMU Prediction 10/4/25 College Football Picks Today

In this article, we will formulate a Syracuse vs SMU Prediction for this College Football Week 6 game on Saturday, October 4th at the Gerald J. Ford Stadium. Let’s take a look at the prediction for this College Football matchup.

SMU Preview

SMU has a 2-2 record this season and is sitting on the 12th place of the Atlantic Coast. They are 0-4 ATS, 1-3 in Over/Under and have a 1-1 away record and 1-1 home record. The Mustangs are coming off a 24-35 road loss at Texas Christian and are playing Stanford and Clemson next.

Offensively, the Mustangs average 34.8 points per game, which ranks 46th in the nation. Defensively, they allow 26.5 points per game, which is 90th. SMU averages 422.5 total yards per game, with 141.0 rushing yards and 281.5 passing yards per game. They allow 449.3 total yards per game, with 114.8 rushing and 334.5 passing yards per game.

Kevin Jennings leads the Mustangs with 1126 passing yards and 68.3% completed passes. TJ Harden leads the team in rushing yards, with 309, while TJ Harden has a team-high 19 caught passes for 365 receiving yards, and has 3 touchdowns. Defensively, Isaiah Nwokobia has a team-high 31 total tackles, 17 of them solo. Cam Robertson leads the Mustangs in sacks, with 3, while Isaiah Nwokobia has one interception.

Syracuse Preview

Syracuse has a 3-2 record this season and is sitting on the 7th place of the Atlantic Coast. They are 2-2-1 ATS, 3-2 in Over/Under and have a 1-0 away record and 2-1 home record. The Orange are coming off a 3-38 home loss vs Duke and are playing Pitt and Georgia Tech next.

Offensively, the Orange average 31.2 points per game, which ranks 64th in the nation. Defensively, they allow 29.6 points per game, which is 112th. Syracuse averages 441.0 total yards per game, with 112.0 rushing yards and 329.0 passing yards per game. They allow 464.6 total yards per game, with 174.0 rushing and 290.6 passing yards per game.

Steve Angeli leads the Orange with 1317 passing yards and 62.8% completed passes. Yasin Willis leads the team in rushing yards, with 296, while Johntay Cook II has a team-high 24 caught passes for 308 receiving yards, and has 1 touchdown. Defensively, Gary Bryant III has a team-high 27 total tackles, 11 of them solo. Braheem Long Jr. leads the Orange in sacks, with 2, while Darian Chestnut has two interceptions.

Syracuse Orange @ SMU Mustangs Betting Trends: Week 6

 

Why the SMU Mustangs will win

Why the Syracuse Orange will win

Total Points Facts

SMU Mustangs Player Prop Facts

Syracuse Orange Player Prop Facts

Matchup/League Facts

Syracuse vs SMU Prediction

In this Syracuse vs SMU Prediction, SMU is coming as -17-point home favorites, with the total set at 58.5 points. The Mustangs have both a better offense and defense than the Orange, but they have less wins this season and are just 1-1 at home, and have failed to cover all of their four games played. On the flip side, Syracuse is 3-1 in their last four games, and have won and covered their only game on the road, so I like them to keep this one relatively close. Take Syracuse and the +17 points in this one.

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