USC vs Michigan State Prediction Football Picks Today 9/20/25

The Michigan State Spartans and USC Trojans meet Saturday in college football action at Los Angeles Memorial Coliseum. Here’s a USC vs Michigan State Prediction. This article will include a USC vs Michigan State Pick.

Michigan State Spartans Betting Preview

The Michigan State Spartans beat Boston College and Youngstown State and plays Nebraska next. The Michigan State Spartans have won 4 of their last 5 games. Aidan Chiles is completing 71.6 percent of his passes for 656 yards, 6 touchdowns and 1 interception. Nick Marsh and Omari Kelly have combined for 378 receiving yards and 3 touchdowns, while Michael Masunas has 6 receptions.

The Michigan State Spartans ground game is averaging 168 yards per contest, and Makhi Frazier leads the way with 206 yards and 2 touchdowns. Defensively, Michigan State is allowing 23.3 points and 337.7 yards per game. Jordan Hall leads the Michigan State Spartans with 27 tackles, Anelu Lafaele has 2 sacks and Armorion Smith has 1 interception.

USC Trojans Betting Preview

The USC Trojans beat Purdue and Georgia Southern, and they play Illinois next. The USC Trojans have won 7 of their last 9 games. Jayden Maiava is completing 68.6 percent of his passes for 989 yards, 6 touchdowns, and 0 interceptions. Makai Lemon and Ja’Kobi Lane have combined for 550 receiving yards and 3 touchdowns, while Lake McRee has 7 receptions.

The USC Trojans ground game is averaging 240 yards per contest, and Waymond Jordan leads the way with 286 yards and 3 touchdowns. Defensively, USC is allowing 16.7 points and 319.3 yards per game. Eric Gentry leads the USC Trojans with 21 tackles, Kameryn Fountain has 2.5 sacks and Bishop Fitzgerald has 3 interceptions.

Michigan State Spartans @ USC Trojans Betting Trends: Week 4

 

Why the USC Trojans will win

Why the Michigan State Spartans will win

Total Points Facts

USC Trojans Player Prop Facts

Michigan State Spartans Player Prop Facts

Matchup/League Facts

USC vs Michigan State Prediction

Michigan State is off to a fine start and brings that physicality in the trenches, but Sparty is 2-9-2 ATS in its last 13 games as an underdog of 14 or more points. USC also has an explosive passing attack, and Michigan State is 117th in pass defense.

USC has covered 5 of its last 6 games as a favorite of 14 or more points, and that includes 3 wins this season by an average of 38.3 points. I’m not sure Michigan State will be able to slow down this USC passing attack or has the horses to respond. I’ll lay the points with the Trojans on Saturday night.

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