Major League Baseball presents Draftkings baseball fans with an interleague matchup featuring the Baltimore Orioles and the San Diego Padres. Let’s take a look at this MLB game from a DFS perspective.
Before we dive into the Baltimore Orioles vs. San Diego Padres game let’s review the rules for the Draftkings MLB single game showdown contest.
Draftkings Single Game Showdown Contest Rules
You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.
The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.
If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.
*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.
Here are my Draftkings picks for tomorrow night’s Orioles vs. Padres matchup.
Draftkings MLB DFS Picks
Captain-Dylan Cease, Starting Pitcher, San Diego Padres $11,800
On Monday night, Major League Baseball presents the opening game of a three-game interleague series featuring the Baltimore Orioles and the San Diego Padres.
How are these two teams playing entering this MLB game? The San Diego Padres are playing below average baseball entering tomorrow evening’s matchup with the Baltimore Orioles. The Padres have five of the team’s last seven games played in the 2025 MLB regular season, including a 7-4 loss to the Minnesota Twins two days ago.
Similar to the San Diego Padres, the Baltimore Orioles arrive at tomorrow’s interleague game playing subpar baseball. The Orioles have lost six of the team’s last seven games played in 2025, including a 15-8 loss to the San Francisco Giants earlier this week.
Now that we have determined how both of these teams are currently playing let’s shift our focus to tomorrow evening’s contest. Starting pitcher Dylan Cease has been a solid performer for the San Diego Padres starting pitching rotation this season. Having stated that, how has Cease pitcher performed from a statistical standpoint? Let’s review Cease’s relevant game data from the 2025 MLB regular season to answer that question.
In 27 starts this season, San Diego Padres starting pitcher Dylan Cease has compiled a 6-11 (win-loss record), a 4.82 ERA (Earned Run Average) and a 1.33 WHIP (Walks and Hits per Inning Pitched) in 2025. It should also be mentioned that Cease has amassed a massive 183 strikeouts (sixth in MLB) while allowing 61 walks in 142 innings pitched this season.
As I noted in the rules section above, selecting the correct player at the captain position for a Draftkings MLB showdown lineup is absolutely vital if you hope to win a large field GPP (guaranteed prize pool) DFS contest. Keep that in mind as you construct your lineups.
In my opinion, Dylan Cease is the most likely player to post the most Draftkings points in this MLB game. For that specific reason, I am backing San Diego Padres starting pitcher Dylan Cease at the captain position for this one game MLB DFS slate.
Flex plays I like to play well in this MLB regular season contest (Draftkings price noted): Kyle Bradish, Starting Pitcher (Baltimore Orioles) $11,400: Jackson Holiday, Second Baseman (Baltimore Orioles) $8,200.