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San Diego Padres vs San Francisco Giants MLB Picks, Odds, Predictions 9/22/21

San Francisco Giants (98-53) vs. San Diego Padres (76-74)
September 22, 2021 10:10 pm EDT
The Line: San Diego Padres -152 / San Francisco Giants +115; Over/Under: -7.5
(Get latest betting odds)

The San Francisco Giants and San Diego Padres meet Wednesday in MLB action at Petco Park. The Giants look for a win after winning 12 of their last 15 games. The Padres need a win to snap a four-game losing streak.

The San Francisco Giants have scored eight runs in their last three games and four or more runs in seven of their last nine games. The Giants have won 12 of their last 14 games when scoring four or more runs. Brandon Crawford leads the Giants with 132 hits and 82 RBI while Buster Posey and Mike Yastrzemski have combined for 205 hits and 107 RBI. Scott Kazmir gets the ball, and he is 0-1 with a 6.43 ERA and seven strikeouts this season. Kazmir is 1-0 with a 4.91 ERA and 32 strikeouts in his career against the Padres.

The San Diego Padres have scored 14 runs in their last three games and four or more runs in four of their last eight games. The Padres have won six of their last nine games when scoring four or more runs. Manny Machado leads the Padres with 146 hits and 93 RBI while Jake Cronenworth and Eric Hosmer have combined for 266 hits and 126 RBI. Vince Velasquez gets the ball, and he is 3-7 with a 6.09 ERA and 89 strikeouts this season. Velasquez is 1-4 with a 4.02 ERA and 38 strikeouts in his career against the Giants.

The Giants are 4-0 in their last 4 during game 2 of a series and 21-9 in their last 30 Wednesday games. The Padres are 2-6 in their last 8 Wednesday games and 2-8 in their last 10 overall. The under is 4-1 in Giants last 5 Wednesday games. The over is 4-1 in Padres last 5 overall. The Giants are 3-7 in the last 10 meetings in San Diego.

Kazmir is approaching 38 years old and has pitched just seven innings since the 2016 season. Not ideal for the Giants. However, Velasquez has been terrible this season, and that includes 31 hits and 28 earned runs allowed in his last 21.2 innings. The Giants are the better team here and just find ways to win, and last night was no different. I don’t expect this game to be either. Give me the plus money.

Randy Chambers's Free Pick: San Francisco Giants +115

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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