White Sox vs. Astros Pick – MLB Predictions & Odds 5/12/23

Chris RuffoloMay 11, 2023
White Sox vs. Astros Pick – MLB Predictions & Odds 5/12/23 player photo
Credit: USA Today Sports

The Houston Astros and the Chicago White Sox meet in MLB action from Guaranteed Rate Field on Friday night. Let’s dive into the odds, starting pitching matchup, history and make a prediction for this game.


Houston is listed as a -145 road favorite while Chicago is a +125 home underdog. The total for this game is set at 9 runs.

Starting Pitching Matchup

J.P. France will start for Houston and is 0-0 with a 0.00 ERA and 5 strikeouts this season. Michael Kopech will start here and is 1-3 with a 5.97 ERA and 36 strikeouts this season.

Matchup History

Chicago’s 6-3 win over Houston on April 2nd, 2023, snapped Houston’s two-game win streak in this head-to-head matchup.


Houston is 29-11 in their last 40 road games and 134-66 in their last 200 series-opening games while the over is 7-2 in their last 9 games against the AL Central. Chicago is 8-18 in their last 26 home games and 8-20 in their last 28 games overall while the over is 7-1-1 in their last 9 games against the AL West.


I’m backing the Astros here. I’m just not looking to back the White Sox at the best of times but with Michael Kopech on the mound against a still decent Astros lineup, this could spell trouble. J.P. France was solid in his debut and while I don’t rush to back rookies, I think could be a good spot for him. I’ll take Houston in this one.

Chris Ruffolo's Free Pick:Houston -145
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Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg