Angels vs Astros Prediction 9/28/25 MLB Picks Today

The Houston Astros and Los Angeles Angels meet Sunday in MLB action at Angel Stadium. Here’s a Angels vs Astros Prediction. This article will include a Angels vs Astros Pick.

Houston Astros Betting Preview

The Houston Astros are 86-74 on the year after playing the Athletics. The Houston Astros are batting .250 on the season, have a .315 OBP, and a .397 slugging percentage. The Houston Astros pitching staff has a 3.88 ERA and a 1.23 WHIP. Jose Altuve leads the Houston Astros with 156 hits and 77 RBI while Jeremy Pena and Christian Walker have combined for 289 hits and 150 RBI.

Lance McCullers Jr.  gets the ball for the Houston Astros, and he is 2-5 with a 6.71 ERA and 57 strikeouts this season. McCullers is 7-5 with a 3.09 ERA and 116 strikeouts in his career against the Los Angeles Angels.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 72-89 on the year after playing the Royals. The Los Angeles Angels are batting .226 on the season, have a .298 OBP, and a .398 slugging percentage. The Los Angeles Angels pitching staff has a 4.88 ERA and a 1.43 WHIP. Taylor Ward leads the Los Angeles Angels with 131 hits and 103 RBI while Zach Neto and Nolan Schanuel have combined for 258 hits and 115 RBI.

Sam Aldegheri gets the ball for the Houston Astros, and he is 0-1 with a 8.00 ERA and 7 strikeouts this season. This will be Aldegheri’s second career game against the Los Angeles Angels.

Houston Astros @ Los Angeles Angels Betting Trends: September 28, 2025

 

Why the Los Angeles Angels will win

 

Why the Houston Astros will win

Total Runs Facts

Los Angeles Angels Player Prop Facts

Houston Astros Player Prop Facts

Angels vs Astros Prediction

Neither the Angels nor Astros care about this game now that they’re out of the playoff race. Throw in care free ball and two struggling pitchers, and we should see some offense. McCullers has a 6.71 ERA and 1.85 WHIP on the season, and he’s allowed 11 hits and 5 earned runs in his last 8 innings. Aldegheri has just 9 innings under his belt and has allowed 13 hits and 8 runs in those frames while walking 7. Expect some offense. Forget the side and give me the over.

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