Diamondbacks vs Reds Prediction 8/22/25 MLB Picks Today

The Cincinnati Reds and the Arizona Diamondbacks meet Friday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs Reds Prediction.

Starting Pitching Matchup

The Cincinnati Reds will send out Zack Littell for the start here and Littell is 9-8 with a 3.52 ERA and 103 strikeouts this season. In his career, Littell is 0-1 with a 7.99 ERA and 5 strikeouts against Arizona. The Arizona Diamondbacks will send out Ryne Nelson for the start here and Nelson is 6-3 with a 3.58 ERA and 99 strikeouts this season. This will be Nelson’s second career start against the Reds.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to rebound from a 2-1 loss at the hands of the Angels last time out to sit at 67-61 this season. After this series, the Reds will head on the road once again for a series against the Los Angeles Dodgers.

Reds Have Three-Game Win Streak Snapped

Elly De La Cruz has 135 hits with 19 home runs, 76 RBIs, 25 doubles and 31 stolen bases while TJ Friedl has 121 hits with 18 doubles, 10 home runs and 40 RBIs with 11 stolen bases. Gavin Lux has added 100 hits with 21 doubles and 48 RBIs while Spencer Steer has 15 home runs and 59 RBIs and Matt McLain has added 11 homers, 40 RBIs and 16 stolen bases as well on the year. Jose Trevino’s also chipped in 19 doubles as well this season.

Why the Cincinnati Reds will win

Cincinnati Reds Player Prop Facts

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their win over the Cleveland Guardians last time out to sit at 62-66 this season. After this series, the Diamondbacks will head on the road for a series against the Milwaukee Brewers.

Diamondbacks Win Back-To-Back Games

Corbin Carroll has 113 hits with 27 home runs, 65 RBIs, 16 triples and 22 doubles this season. Carroll also has 17 stolen bases and Geraldo Perdomo has a team-high 22 stolen bases as well as 13 home runs and 81 RBIs with a team-high 134 hits this season. Ketel Marte’s added 23 home runs and 56 RBIs as well on the year and Lourdes Gurriel has 115 hits with 23 doubles, 17 home runs and 71 RBIs.

Why the Arizona Diamondbacks will win

Arizona Diamondbacks Player Prop Facts

Total Runs Facts

Diamondbacks vs Reds Prediction

I’m on the Diamondbacks in this one. I get the case to be made for the Reds, as they’re still the only team here that’s realistically in the playoff race. However, Arizona’s still been playing some decent baseball despite the fact that they traded away a lot of assets at the trade deadline. Chase Field has had a tendency to be fairly hitter friendly, so for a pitcher like Littell, who has had major problems with giving up home runs this season, I think that could prove to be problematic here. Give me the Diamondbacks at home in this one.

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