Diamondbacks vs Guardians Prediction 8/20/25 MLB Picks Today

The Cleveland Guardians and the Arizona Diamondbacks meet Wednesday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Parker Messick for his major league debut here and Messick had a 5-6 record with a 3.47 ERA and 119 strikeouts in triple A this season. Brandon Pfaadt will get the start for the Diamondbacks and is 12-8 with a 5.08 ERA and 108 strikeouts this season. This will be Pfaadt’s second career start against Cleveland.

Cleveland Guardians Recap

The Cleveland Guardians will look to rebound from their 6-5 loss at the hands of the Arizona Diamondbacks on Tuesday to sit at 64-61 this season. After this series, the Guardians will head on the road for a series against the Texas Rangers.

Guardians Drop 4 Of Their Last 5

Steven Kwan has 131 hits as part of a .281 batting average and 10 home runs, 22 doubles and 40 RBIs. Kyle Manzardo has 81 hits with 14 doubles, 2 triples, 21 home runs and 55 RBIs as well this year. Gabriel Arias has 20 doubles but also 113 strikeouts and Manzardo has 94 strikeouts so far this season. Arias has also added 9 home runs and 45 RBIs and Jose Ramirez has chipped in 25 home runs and 64 RBIs with 35 stolen bases as well. Carlos Santana has also added 87 hits with 11 home runs and 51 RBIs as well this season.

Why the Cleveland Guardians will win

Cleveland Guardians Player Prop Facts

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their win over the Guardians from Tuesday’s matchup to climb to 61-65 this season. After this series, the Diamondbacks will welcome the Cincinnati Reds to town for a set.

Diamondbacks Snap Three-Game Losing Streak

Corbin Carroll has 109 hits with 27 home runs, 64 RBIs, 14 triples and 22 doubles this season. Carroll also has 16 stolen bases and Geraldo Perdomo has a team-high 21 stolen bases as well as 13 home runs and 79 RBIs with a team-high 130 hits this season. Ketel Marte’s added 23 home runs and 56 RBIs as well on the year and Lourdes Gurriel has 111 hits with 23 doubles, 16 home runs and 66 RBIs.

Why the Arizona Diamondbacks will win

Arizona Diamondbacks Player Prop Facts

Total Runs Facts

Diamondbacks vs Guardians Prediction

I’m on the Diamondbacks here. I just don’t know what to expect from Messick in his debut, and this is still an Arizona offense that’s been able to drum up some runs against right-handed pitching as of late. Cleveland does have the better bullpen, but I think Arizona can stake their pitching staff enough runs to get the win in this one to start the series. Give me Arizona in this one.

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