Diamondbacks vs Astros Prediction 7-21-25 MLB Picks

The Houston Astros and the Arizona Diamondbacks meet Monday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs Astros Prediction.

Starting Pitching Matchup

The Houston Astros will start Colton Gordon here, and Gordon is 3-2 with a 4.67 ERA and 44 strikeouts this season. This will be Gordon’s first career start against the Diamondbacks. The Arizona Diamondbacks will send out Zac Gallen here, and Gallen is 7-10 with a 5.40 ERA and 110 strikeouts this season. In his last five starts against the Astros, Gallen is 1-1 with a 3.16 ERA and 32 strikeouts.

Houston Astros Recap

The Houston Astros come into this game looking to build on their 11-3 win over the Seattle Mariners in Sunday’s series finale to sit at 57-42 on the year. After this series, the Astros will head home for a series against the Athletics.

Astros Snap Three-Game Losing Streak

Jose Altuve has 103 hits, including 16 doubles, 17 home runs, and 53 RBIs. Jeremy Pena also has 102 hits with 18 doubles, 11 homers, and 40 RBIs with 15 stolen bases as well. Jake Meyers has 15 doubles as well, and Christian Walker has 13 home runs and 50 RBIs but has also accrued a team-high 107 strikeouts so far this season. Altuve also has 6 stolen bases while Jake Meyers has 14 stolen bases this season. Isaac Paredes also has a team-high 19 home runs with 50 RBIs of his own, and Cam Smith has contributed 7 homers and 42 RBIs.

Why the Houston Astros will win

Houston Astros Player Prop Facts

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their 5-3 win over the St. Louis Cardinals last time out to improve to 50-50 on the year. After this series, the Diamondbacks will head on the road for a series against the Pittsburgh Pirates.

Diamondbacks Win Four In A Row

Corbin Carroll has 84 hits with 21 home runs, 48 RBIs, 13 triples, and 16 doubles, while Josh Naylor has 98 hits with 19 doubles, 11 home runs, and 58 RBIs as well this season. Eugenio Suarez has also added 35 home runs and 85 RBIs, while Geraldo Perdomo has 72 RBIs. Naylor has also chipped in 11 stolen bases as well up to this point in the year, while Suarez has the unfortunate distinction of leading the Diamondbacks with 105 strikeouts so far this season. Carroll also has 12 stolen bases, and Perdomo has a team-high 15 stolen bases as well this season.

Why the Arizona Diamondbacks will win

Arizona Diamondbacks Player Prop Facts

Total Runs Facts

Diamondbacks vs Astros Prediction

I’m on Arizona here. I get the case to be made for Houston in this one, as the Astros are still one of the better teams in the American League, but we’ve started to see Colton Gordon stumble in spots. The Diamondbacks are still a team that’s crushing left-handed pitching right now. I think Arizona being at home continues to pay off here, and I’ll back the Diamondbacks in this one.

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