Arizona Diamondbacks vs Philadelphia Phillies Prediction 9/21/25 MLB Picks Today

The Philadelphia Phillies and the Arizona Diamondbacks meet Sunday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Philadelphia Phillies vs. Arizona Diamondbacks prediction.

Starting Pitching Matchup

The Philadelphia Phillies will start Ranger Suarez here and Suarez is 12-6 with a 2.84 ERA and 145 strikeouts this season. In his last five starts against Arizona, Suarez is 0-1 with a 6.08 ERA and 24 strikeouts. Eduardo Rodriguez will start here for Arizona and is 8-8 with a 5.12 ERA and 132 strikeouts this season. In his career, Rodriguez is 1-1 with a 3.52 ERA and 35 strikeouts against Philadelphia.


Philadelphia Phillies Recap

The Philadelphia Phillies come into this game looking to bounce back from their 4-3 loss at the hands of teh Diamondbacks in Saturday’s matchup to sit at 92-63 this season. After this series, the Phillies will go home for their set against the Miami Marlins

Phillies Still 8-3 In Their Last 11

Nick Castellanos has 134 hits with 27 doubles including 17 home runs and 69 RBIs while Kyle Schwarber has 138 hits with a team-high 53 home runs and 128 RBIs but also has a team-high 183 strikeouts as well on the year. Bryce Harper has 12 stolen bases, 32 doubles, 27 home runs and 75 RBIs. Trea Turner also has 179 hits with 7 triples, 15 home runs, 69 RBIs and a team-high 36 stolen bases. Max Kepler has 18 doubles and Bryson Stott has 20 doubles, 3 triples, 12 homers and 65 RBIs while Stott also has 23 stolen bases as well this season.

Why the Philadelphia Phillies will win

Philadelphia Phillies Player Prop Facts

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to Saturday’s win over Philadelphia, improving to 78-77 as a result. After this series, the Diamondbacks will square off against the Los Angeles Dodgers in a series at home.

Diamondbacks Snap Two-Game Slide

Corbin Carroll has 140 hits with 30 home runs, 78 RBIs, 17 triples and 30 doubles this season. Carroll also has a team-high 29 stolen bases and Geraldo Perdomo has 26 stolen bases as well as 19 home runs and 97 RBIs with a team-high 163 hits this season. Ketel Marte’s added 26 home runs and 67 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Why the Arizona Diamondbacks will win

Arizona Diamondbacks Player Prop Facts

Total Runs Facts

Philadelphia Phillies vs. Arizona Diamondbacks Prediction

I’m backing the Phillies here. I was on Arizona on Saturday but I’m switching back to Philly on Sunday as I just feel like Ranger Suarez is the far more reliable left-handed starter in this game and while I’m also not fond of Philadelphia’s bullpen, Arizona’s bullpen in September has the third-highest bullpen ERA and is back to riding the struggle bus like the Diamondbacks’ bullpens of the last couple of seasons. I think Philly wins the series here so give me the Phils behind another strong start from Suarez.

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