Astros vs Athletics Prediction 9/25/25 MLB Picks Today

In this article, we will formulate an Astros vs Athletics Prediction for this MLB game on Thursday, September 25^th at the Sutter Health Park in the third game of this series, with the Athletics having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Athletics Preview

The Athletics have a 75-83 record this season and are sitting on the last place of the AL West. The Athletics have a 35-42 home record and are 76-75 in over/under. They are coming off a 6-0 home victory over the Astros, and have back-to-back wins. Under is 11-4 in their last 15 games and are playing the Royals next.

The Athletics have a .253 batting average this season, .318 OBP and .432 Slugging percentage. Athletics’ pitching staff has a 4.66 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 163 hits, while Jacob Wilson is the team’s best hitter with a .315 batting average. Tyler Soderstrom adds a team-high 93 RBI, while Nick Kurtz adds a team-high 33 home runs.

J.T. Ginn (R) is the projected starter for the Athletics, and he has a 4-6 record, 4.57 ERA, and 1.32 WHIP.

Houston Astros Preview

The Houston Astros have an 84-74 record this season and are sitting on the second place of the AL West. The Astros have a 38-39 road record and 72-80 in over/under. They are coming off a 0-6 road defeat by the A’s, and have five consecutive losses. They are playing the Angels next.

The Astros have a .250 batting average this season, .315 OBP and .396 slugging percentage. Houston’s pitching staff has a 3.89 ERA and 1.22 WHIP. Jose Altuve leads the Astros with 153 hits, adding a team-high 26 home runs. Jeremy Pena is the team’s best hitter with a .304 batting average, while Christian Walker leads the team in RBI with 82.

Framber Valdez (L) is the projected starting pitcher for the Astros, and he has a 12-11 record, 3.75 ERA and 1.24 WHIP.

Houston Astros @ Athletics Betting Trends: September 25, 2025

• Probable Starting Pitcher: J.T. Ginn      Record this season: 4-6      ERA: 4.57
• Home Record: 1-4
• Last 5 against Astros: 1-0

Why the Athletics will win

• The Athletics have won each of their last six games as underdogs against the Astros.
• The Astros have lost six of their last seven games as road favorites against American League opponents.
• The Athletics have covered the run line each of their last eight games against teams that held a winning record.
• The Astros have failed to cover the run line each of their last six road games against AL West opponents that held a losing record.
• The Athletics have won the first inning in four of their last five games against the Astros.
• The Athletics have led after 5 innings in each of their last seven games against the Astros.
• The Athletics have led after 3 innings in each of their last six Thursday home games.

• Probable Starting Pitcher: Framber Valdez      Record this season: 12-11      ERA: 3.75
• Road Record: 6-7
• Last 5 against Athletics: 3-1

Why the Houston Astros will win

• The Astros have won each of their last nine day games against AL West opponents following a road loss.
• The Athletics have lost eight of their last nine day games against AL West opponents.
• The Athletics have failed to cover the run line in each of their last four day games against AL West opponents.
• The Astros have covered the run line each of their last six Thursday day games against American League opponents that held a losing record.
• The Athletics have lost the first inning in each of their last four day games against AL West opponents.
• The Athletics have trailed after 5 innings in each of their last four day games against AL West opponents.
• The Athletics have trailed after 3 innings in each of their last three day games against AL West opponents.

Total Runs Facts

• Each of the Astros’ last six road games against American League opponents have gone UNDER the total runs line.
• Eight of the Athletics’ last nine games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Athletics’ last six day games against AL West opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Astros’ last 10 road games against AL West opponents.

Athletics Player Prop Facts

• Shea Langeliers has hit a home run in each of the Athletics’ last four games as underdogs against the Astros.
• Shea Langeliers has recorded a Double in three of the Athletics’ last four games as home underdogs.
• Lawrence Butler has recorded at least one hit in nine of his last 10 home appearances against opponents that held a winning record.
• Jacob Wilson ranks 2nd amongst qualified players for Batting Average (.315) this season.

Houston Astros Player Prop Facts

• Framber Valdez has recorded a win in seven of his last eight appearances in day games against AL teams that held a losing record.
• Framber Valdez has recorded five or more strikeouts in nine of his last 10 appearances against AL opponents that held a losing record.
• Christian Walker has recorded at least one hit in each of the Astros’ last 18 road games against opponents that held a losing record.
• Yordan Alvarez has hit a home run in four of his last seven appearances with the Astros as road favorites against AL West opponents.
• Yordan Alvarez has recorded a Double in each of his last three road appearances against the Athletics.

Matchup/League Facts

• The Athletics rank 2nd in the league for doubles this season (287).
• The Athletics rank 29th in the league for home runs allowed this season (217).
• The Astros rank 1st in the league for strikeouts this season (1468).
• The Astros rank 27th in the league for steals this season (78).

Astros vs Athletics Prediction

The Athletics have won their last 8 head-to-head meetings against the Astros, and are 4-2 in their last 6 home meetings against the Astros. Under is 5-1 in their last 6 meetings.

In this Astros vs Athletics Prediction, the Astros are coming as -120 road favorites. The Astros are struggling in the worst possible time, and have practically lost the AL West title to the Mariners. They are now fighting for a wild card spot, and they are putting Valdez on the mound, who has been good this season, but struggling mightily lately, with 19 earned runs across his last four starts. Ginn has been playing good for the A’s, with just three earned runs in his last three starts, so I like the A’s as home dogs in this one. Take the Athletics for plus money in this one.