Astros vs Athletics Prediction 5/28/25 MLB Picks Today

In this article, we will formulate an Astros vs Athletics prediction for this MLB game on Wednesday, May 28, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

Athletics Betting Preview

The Athletics (23-32, 14-13 Away) managed to avoid being swept by the Philadelphia Phillies with a win and snapped an 11-game losing skid along the way. During that negative stretch, the A’s were swept by the Giants and Angels, while they opened this series against the Houston Astros with a massive 11-1 loss. JP Sears took the loss in the worst display of his career, in which he allowed nine runs on ten hits with one strikeout and one walk in 3.1 innings.

This season, the Athletics average 4.28 runs per game (13th in the MLB) on a .256/.321/.419 triple-slash. When it comes to pitching, the Athletics’ staff has a 5.29 ERA (28th) and 1.48 WHIP (28th). Tyler Soderstrom leads the Athletics with a .264 batting average, ten home runs, and 31 RBI this season.

Luis Severino will take the mound for the Athletics on Wednesday. The 31-year-old right-hander has a 1-4 record in 11 starts this year with a 4.11 ERA and 1.26 WHIP in 65.2 innings.

Houston Astros Betting Preview

The Houston Astros (29-25, 19-10 Home) split the series with the Texas Rangers, lost to the Tampa Bay Rays, and defeated the Seattle Mariners. Houston opened this series against the Athletics with an 11-1 victory, which means the Astros are on a three-game winning run now. Jose Altuve led the offense with two homers and three RBI, while Hunter Brown got the win after allowing one run on six hits with eight strikeouts and no walks across 6.0 innings of work.

This year, the Astros average 4.04 runs per game (21st in the MLB) on a .254/.323/.386 triple-slash. When it comes to pitching, the Astros’ staff has a 3.42 ERA (8th) and 1.16 WHIP (2nd). Isaac Paredes leads the Astros with a .270 batting average, 11 home runs, and 31 RBI this season.

The projected starting pitcher for the Astros is Lance McCullers Jr., who is 0-1 in four starts this season, with a 6.57 ERA and 2.03 WHIP in 12.1 innings.

Total Runs Facts

• Eight of the Athletics’ last nine games against American League opponents have gone OVER the total runs line.
• Five of the last six games between the Athletics and Astros have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 13 of the Athletics’ last 14 games as road underdogs against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Astros’ last eight games as favorites.

Matchup/League Facts

• The Astros rank T28th in the league for steals this season (24).
• The Astros rank T3rd in the league for runs allowed this season (191).
• The Athletics rank 29th in the league for hits allowed this season (517).
• The Athletics rank 29th in the league for runs allowed this season (319).

Astros vs Athletics Prediction

The teams have traded wins in the past couple of years, each recording five in the last ten H2H duels. Five of the previous six H2Hs went Over, including each of the last three, and I am going with another Over here. Luis Severino struggled earlier this month as he allowed 12 runs in two starts, and although he improved in his latest two starts, I think the Astros will trouble him early on in this one. Needless to say that the A’s have one of the worst bullpens in the MLB, which is also another strong argument for the Over. Lance McCullers Jr. is still displaying rust after coming back to the mound from a lengthy injury, so I expect him to surrender some runs here.