Astros vs Cardinals Prediction 4/17/26 MLB Picks Today

In this article we will formulate an Astros vs Cardinals prediction for this MLB game on Friday, April 17th at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 8-12 this year after they won two out of three against the Rockies by scores of 7-6, 3-1, and 2-3. In game three, Houston led 2-0 in the first inning, but they went scoreless over the last eight innings in the low scoring loss. The Astros recorded five hits in the game and they were led by Alvarez and Loperfido, who both had one RBI. Weiss allowed three hits and two earned runs over 3.2 innings, while Roa was charged with the loss. Prior to that series, Houston lost all three against the Mariners and all three against the Rockies. 

This season, Houston has a 6.01 ERA with a 1.67 WHIP and a .265 opponent batting average, while they have scored 107 runs with a .264 batting average and a .358 on base percentage. Yordan Alvarez has led the Astros with seven home runs and 18 RBIs, while Christian Walker has added four home runs and 16 RBIs. The projected starting pitcher for Houston is Peter Lambert, who is making his first appearance of the year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 10-8 this season after they won two out of three against the Guardians by scores of 3-9, 6-5, and 5-3. In game three, St. Louis had their lead cut to 4-3 in the top of the seventh inning, but they added a run in the bottom half of the inning to seal the win. The Cardinals recorded nine hits in the game and they were led by Burleson, who went 2-5 with two RBIs. May allowed six hits and one earned run over 6.0 innings for the win, while O’Brien picked up the save. Prior to that series, St. Louis lost two out of three against the Red Sox, but won two out of three against the Nationals before that. 

This season, St. Louis has a 4.94 ERA with a 1.45 WHIP and a .264 opponent batting average, while they have scored 80 runs with a .231 batting average and a .326 on base percentage. Jordan Walker has led the Cardinals with eight home runs and 15 RBIs, while Alec Burleson has added two home runs and 14 RBIs. The projected starting pitcher for St. Louis is Kyle Leahy, who is 1-2 with a 5.14 ERA and a 1.71 WHIP over 14.0 innings pitched this season. 

Why the Houston Astros will win

Why the St. Louis Cardinals will win

Total Runs Facts

Houston Astros Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

Astros vs Cardinals Prediction 

Houston comes into this matchup after winning their last series against Colorado, but they struggled in the two series prior to that. The Astros are 7-3 at home this year, while the Cardinals are 3-3 on the road. St. Louis just won two out of three against the Guardians, but they have allowed at least five runs in four of their last five. I don’t know what to expect from Lambert on the mound, but I don’t like how Leahy has pitched. Take the Astros at home here. 

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