Astros vs Cubs Prediction 6/28/25 MLB Picks Today

The Chicago Cubs and Houston Astros meet Saturday in MLB action at Daikin Park. Here’s an Astros vs Cubs Prediction. This article will include an Astros vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 48-34 on the year and play the Guardians, Cardinals, and Twins next. The Chicago Cubs are batting .255 on the season, have a .325 OBP, and a .444 slugging percentage. The Chicago Cubs pitching staff has a 3.89 ERA and a 1.26 WHIP. Nico Hoerner leads the Chicago Cubs with 88 hits and 34 RBI, while Kyle Tucker and Pete Crow-Armstrong have combined for 171 hits and 110 RBI.

Colin Rea gets the ball for the Chicago Cubs, and he is 4-3 with a 4.42 ERA and 54 strikeouts this season. Rea is 1-1 with a 4.66 ERA and 9 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 49-33 on the year and play the Rockies, Dodgers, and Guardians next. The Houston Astros are batting .256 on the season, have a .322 OBP, and a .400 slugging percentage. The Houston Astros’ pitching staff has a 3.41 ERA and a 1.14 WHIP. Jeremy Pena leads the Houston Astros with 102 hits and 40 RBI, while Jake Meyers and Jose Altuve have combined for 160 hits and 54 RBI.

Lance McCullers Jr. gets the ball for the Houston Astros, and he is 1-2 with a 4.91 ERA and 39 strikeouts this season. This will be McCullers’ first career game against the Chicago Cubs.

Why the Houston Astros will win

Why the Chicago Cubs will win

Houston Astros Player Prop Facts

Chicago Cubs Player Prop Facts

Astros vs Cubs Prediction

I’m not excited to get behind McCullers and his up-and-down performances, especially when he hasn’t pitched in two weeks due to a foot injury. However, Rea has been hittable this season, as he’s allowed 27 hits and 13 runs in his last 21 innings, and he has a .291 allowed batting average in 27.2 road innings. The Astros are on fire right now and their lineup should be excited about this matchup. The Astros are a team to watch if they can stay in this form. Give me the home team on Saturday night.

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