Astros vs Padres Prediction 4/18/25 MLB Picks Today

In this article we will formulate an Astros vs Padres prediction for this MLB game on Friday, April 18th at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 8-10 this year and they have alternated wins and losses over their last 13 games. Houston is coming off of a series loss to St. Louis, where they lost two out of three games by scores of 3-8, 2-0, and 1-4. In that game three loss, the Astros led 1-0 in the first inning, but they allowed three runs in the fifth and one in the sixth for the loss. Houston recorded just four hits and they committed one error in the game, while they were led by Paredes, who had their lone RBI in the loss. Houston started Blanco, who allowed five hits and three earned runs over 5.0 innings in the loss, while VanWey, Okert, Scott, and Sousa pitched the final three innings. 

Prior to that series, the Astros won two out of three against the Angels, but did lose two out of three against the Mariners before that. The Houston pitching staff has a 3.73 ERA with a 1.13 WHIP and a .207 opponent batting average, while their offense has scored 65 runs with a .220 batting average and a .308 on base percentage this season. Isaac Paredes has led Houston with three home runs and 10 RBIs, while Yordan Alvarez has added two home runs and 10 RBIs this year. The projected starting pitcher for Houston is Ryan Gusto, who is 1-1 with a 3.00 ERA and a 1.00 WHIP over 12.0 innings pitched this year. 

San Diego Padres Betting Preview

The San Diego Padres are 15-4 this season and they have won six of their last seven games. San Diego is coming off of a series win against the Cubs, where they won two out of three games by scores of 10-4, 1-2, and 4-2. In their last game, the Padres trailed 1-0 early in the game, but they scored the next three runs and added an insurance run in the eighth for the win. The Padres recorded seven hits in the game and they were led by Tatis Jr. and Machado, who both had two RBIs in the win. San Diego started Pivetta, who allowed four hits and one earned run over 6.0 innings in the win, while Suarez picked up the save in the ninth. 

Prior to that series, the Padres won all three against the Rockies and two out of three against the Athletics. The San Diego pitching staff has a 2.56 ERA with a 1.07 WHIP and a .193 opponent batting average, while their offense has scored 88 runs with a .274 batting average and a .348 on base percentage this season. Fernando Tatis has led San Diego with six home runs and 14 RBIs, while Gavin Sheets has added two home runs and 10 RBIs this year. The projected starting pitcher for San Diego is Kyle Hart, who is 2-0 with a 5.40 ERA and a 1.11 WHIP over 11.2 innings pitched this season. 

Why the Astros will beat the Padres

Why the Padres will beat the Astros

Total Runs Facts

Houston Astros Player Prop Facts

San Diego Padres Player Prop Facts

Matchup/League Facts

Astros vs Padres Prediction 

San Diego comes into this series as one of the top teams in the MLB right now, but they are just 3-3 on the road. The Padres have won six of their last seven games and they have one of the best team ERA’s in all of baseball. Houston has not been able to string wins together this season and they have scored two runs or fewer in three of their last five games. I know the Astros have had a hard time at the plate, but they should be able to get to Hart, who allowed five earned runs in his first road start. Take the over here. 

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