Astros vs Padres Prediction 4/19/25 MLB Picks Today

The San Diego Padres and the Houston Astros meet Saturday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Astros vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will start Michael King in this one and King is 3-0 with a 2.42 ERA and 24 strikeouts this season. In his career, King is 1-0 with a 2.25 ERA and 11 strikeouts against Houston. The Houston Astros will send out Hayden Wesneski for the start here and Wesneski is 1-1 with a 4.00 ERA and 21 strikeouts this season. In his career, Wesneski is 1-1 with a 3.27 ERA and 6 strikeouts against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to bounce back from a 6-4 loss at the hands of the Astros in Friday’s series opener to fall to 15-5 on the year. After this series, the Padres will head on the road for an interleague series against the Detroit Tigers.

Padres Looking To Rebound

Manny Machado has 23 hits including a team-high 8 doubles and 6 stolen bases while Fernando Tatis Jr. has 24 hits with a team-high 6 home runs and 14 RBIs along with 6 stolen bases of his own this season. Luis Arraez has added 22 hits with 3 doubles while Jackson Merrill’s added 14 hits with 3 home runs and 10 RBIs as well. Xander Bogaerts also has 6 doubles and 4 stolen bases as well this season.

Why the San Diego Padres will win

San Diego Padres Player Prop Facts

Houston Astros Recap

The Houston Astros will be out to keep the ball rolling after their series opening win over the Padres on Friday to improve to 9-10 on the year. After this series, the Astros will welcome the Toronto Blue Jays to town.

Astros Start Series On The Right Foot

Jose Altuve leads the Astros with 23 hits including 3 home runs and 7 RBIs. Jeremy Pena also has 3 homers and 4 stolen bases while Yordan Alvarez has 2 doubles and a team-high 10 RBIs with 15 strikeouts as well. Brendan Rodgers has a pair of doubles while Jake Meyers has a pair of doubles as well and Christian Walker has also accrued a team-high 23 strikeouts so far this season. Altuve also has 3 stolen bases while Jake Meyers has a team-high 6 stolen bases this season.

Why the Houston Astros will win

Houston Astros Player Prop Facts

Total Runs Facts

Astros vs Padres Prediction

I’m on the Padres here. The Padres fell flat in Friday’s opener, but Michael King might be the best option in this Padres’ rotation right now. I trust him more than I trust Hayden Wesneski, who for me has been a glorified spot starter for the better part of his career. He is not someone I’d want in the Astros’ starting rotation if I were an Astros fan. I think the Padres bounce back here and get the win at a nice price on the road in this game. Give me San Diego here.

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