Athletics vs Mariners Prediction 4/22/26 MLB Picks Today

In this article, we will formulate an Athletics vs Mariners Prediction for this MLB matchup on Wednesday, April 22nd in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 10-15 record this season and are sitting in the fourth place of the AL West. They have a 9-7 home record and are coming off a 2-5 home loss against the Athletics. Their previous three games were a 4-6 home loss against the Athletics, and a 5-2 and a 7-3 home win against the Rangers.


The Mariners have a .219 batting average this season, .318 OBP and .355 Slugging percentage. Seattle’s pitching staff has a 3.40 ERA and 1.21 WHIP. Randy Arozarena is the team’s best hitter with a .278 batting average. Luke Raley leads the team in RBI with 13, also adding a team‑high 5 home runs.

Logan Gilbert (R) is the projected starting pitcher for the Mariners, and he has a 1-3 record, 4.03 ERA and 1.17 WHIP.

Athletics Preview

The Athletics have a 13-11 record this season and are sitting in the first place of the AL West. They have an 8-6 away record and are coming off a 5-2 road win against the Mariners. Their previous three games were a 6-4 road win against the Mariners, and a 4-7 home loss and a 7-6 home win against the White Sox.

The Athletics have a .239 batting average this season, .318 OBP and .385 Slugging percentage. Oakland’s pitching staff has a 4.67 ERA and 1.48 WHIP. Shea Langeliers is the team’s best hitter with a .312 batting average, also leading the team in RBI with 14 and adding a team‑high 8 home runs.

Aaron Civale (R) is the projected starting pitcher for the Athletics, and he has a 2-1 record, 3.54 ERA and 1.33 WHIP.

Athletics @ Seattle Mariners Betting Trends: April 22, 2026

 

Why the Seattle Mariners will win

 

Why the Athletics will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Athletics Player Prop Facts

Matchup/League Facts

Athletics vs Mariners Prediction

Both teams are tied 5-5 in their last 10 meetings but the Athletics are 3-1 in their last 4 visits in Seattle.

In this Athletics vs Mariners Prediction, the Mariners are coming as -190 home favorites. The A’s have won both games in this series and are still getting undervalued in this spot. Civale is coming off his worst start of the season but Gilbert has been shaky to start the season and has been struggling at home, with a 1-2 record and 4.30 ERA. Civale has been excellent on the road, with a 1.72 ERA and Seattle ranks just 25th in runs per game, so I like the value with the A’s as underdogs in this spot. Take the A’s on the moneyline for plus money.

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