The St. Louis Cardinals and Milwaukee Brewers meet Sunday in MLB action at American Family Field. Here’s a Brewers vs Cardinals Prediction. This article will include a Brewers vs Cardinals Pick.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 72-77 on the year and play the Reds, Brewers, and Giants next. The St. Louis Cardinals are batting .245 on the season, have a .314 OBP, and a .380 slugging percentage. The St. Louis Cardinals pitching staff has a 4.30 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 128 hits and 63 RBI, while Willson Contreras and Masyn Winn have combined for 248 hits and 130 RBI.
Miles Mikolas gets the ball for the St. Louis Cardinals, and he is 7-10 with a 4.84 ERA and 88 strikeouts this season. Mikolas is 10-7 with a 3.82 ERA and 104 strikeouts in his career against the Milwaukee Brewers.
Milwaukee Brewers Betting Preview
The Milwaukee Brewers are 91-58 on the year and play the Angels, Cardinals, and Padres next. The Milwaukee Brewers are batting .261 on the season, have a .334 OBP, and a .408 slugging percentage. The Milwaukee Brewers pitching staff has a 3.63 ERA and a 1.24 WHIP. Brice Turang leads the Milwaukee Brewers with 155 hits and 75 RBI while Sal Frelick and William Contreras have combined for 286 hits and 131 RBI.
Jose Quintana gets the ball for the Milwaukee Brewers, and he is 11-6 with a 3.88 ERA and 87 strikeouts this season. Quintana is 7-5 with a 4.15 ERA and 76 strikeouts in his career against the St. Louis Cardinals.
St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 14, 2025
- Probable Starting Pitcher: Jose Quintana Record this season: 11-6 ERA: 3.88
- Home Record: 4-4
- Last 5 against Cardinals: 2-2
Why the Milwaukee Brewers will win
- The Brewers have won each of their last 10 games against NL Central opponents that held a losing record.
- The Cardinals have lost each of their last six road games.
- The Cardinals have failed to cover the run line in each of their last eight Sunday day games.
- The Brewers have covered the run line in nine of their last 10 games against NL Central opponents that held a losing record.
- The Brewers have won the first inning in three of their last four day games.
- The Brewers have led after 3 innings in each of their last five day games against NL Central opponents that held a losing record.
- The Cardinals have trailed after 5 innings in each of their last seven road day games.
- Probable Starting Pitcher: Miles Mikolas Record this season: 7-10 ERA: 4.84
- Road Record: 3-6
- Last 5 against Brewers: 2-2
Why the St. Louis Cardinals will win
- The Brewers have lost four of their last five games as home favorites after playing the previous day.
- The Cardinals have won six of their last eight games as underdogs against National League opponents following a loss.
- The Brewers have failed to cover the run line in each of their last six home games following a win.
- The Cardinals have covered the run line in nine of their last 10 day games at American Family Field following a loss.
- The Brewers have trailed after 3 innings in three of their last four games.
- The Brewers have trailed after 5 innings in four of their last five games.
Total Runs Facts
- Eight of the Cardinals’ last nine games following an extra innings loss have gone OVER the total runs line.
- Seven of the Brewers’ last eight home games against NL Central opponents have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Cardinals’ last eight road games against NL Central opponents.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the last 10 day games between the Cardinals and Brewers at American Family Field.
Milwaukee Brewers Player Prop Facts
- Jose Quintana has recorded four or more strikeouts in eight of his last nine appearances against NL Central opponents.
- Jose Quintana has recorded a win in each of his last four appearances against NL Central opponents that held a losing record.
- Jackson Chourio has recorded at least one hit in each of the Brewers’ last 14 games against the Cardinals.
- Christian Yelich has hit a home run in three of the Brewers’ last five home games against NL Central opponents.
- Sal Frelick ranks 9th amongst qualified players for Batting Average (.296) this season.
St. Louis Cardinals Player Prop Facts
- Miles Mikolas has recorded four or more strikeouts in each of his last five appearances in day games against NL teams that held a winning record.
- Miles Mikolas has recorded a win in eight of his last 10 appearances at American Family Field against opponents that held a winning record.
- Brendan Donovan has recorded at least one hit in each of his last nine appearances against the Brewers.
- Willson Contreras has hit a home run in five of his last 10 road appearances after playing the previous day.
- Victor Scott II ranks T10th in the league in Steals (32) this season.
Matchup/League Facts
- The Brewers rank 2nd in the league for runs scored this season (760).
- The Brewers rank 2nd in the league for on-base percentage this season (.334).
- The Cardinals rank T29th in the league for triples this season (8).
- The Cardinals rank 29th in the league for strikeouts this season (1100).
Brewers vs Cardinals Prediction
The Cardinals are having a rough week and look more and more like a team that’s run out of gas. Mikolas has had his hits and misses this season and through 64.2 road innings he has a 6.54 ERA and .320 allowed batting average. Not ideal when going up against a red-hot Brewers team that’s been kind to us all year. Quintana has had his issues at home this season, but this is more about the Brewers being a cash cow and the Cardinals racking up the losses. Give me the Brewers yet again.