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Brewers vs Padres Prediction 6/6/25 MLB Picks Today

San Diego Padres (35-26) vs. Milwaukee Brewers (34-29)
June 6, 2025 8:10 pm EDT
The Line: Milwaukee Brewers -148 / San Diego Padres 124; Over/Under: 8.5
(Get latest betting odds)

The San Diego Padres and Milwaukee Brewers meet Friday in MLB action at American Family Field. Here’s a Brewers vs Padres Prediction. This article will include a Brewers vs Padres Pick.

San Diego Padres Betting Preview

The San Diego Padres are 35-26 on the year and play the Dodgers, Diamondbacks, and Dodgers next. The San Diego Padres are batting .249 on the season, have a .314 OBP, and a .380 slugging percentage. The San Diego Padres pitching staff has a 3.55 ERA and a 1.20 WHIP. Manny Machado leads the San Diego Padres with 72 hits and 31 RBI, while Fernando Tatis Jr. and Luis Arraez have combined for 125 hits and 49 RBI.

Randy Vasquez gets the ball for the San Diego Padres, and he is 3-4 with a 3.99 ERA and 35 strikeouts this season. This will be Vasquez’s second career game against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 34-29 on the year and play the Braves, Cardinals, and Cubs next. The Milwaukee Brewers are batting .239 on the season, have a .315 OBP, and a .368 slugging percentage. The Milwaukee Brewers’ pitching staff has a 3.91 ERA and a 1.32 WHIP. Jackson Chourio leads the Milwaukee Brewers with 70 hits and 37 RBI, while Sal Frelick and Brice Turang have combined for 124 hits and 46 RBI.

Chad Patrick gets the ball for the Milwaukee Brewers, and he is 3-4 with a 2.97 ERA and 57 strikeouts this season. This will be Patrick’s first career game against the San Diego Padres.

Why the Milwaukee Brewers will win

  • The Brewers have won each of their last eight games as home favorites.
  • The Padres have lost four of their last five games against the Brewers following a loss.
  • The Brewers have covered the run line in seven of their last eight games against the Padres following a road win.
  • The Padres have failed to cover the run line in four of their last five night games following a loss.
  • The Padres have trailed after 5 innings in each of their last five games as road underdogs against NL Central opponents.
  • The Brewers have led after 3 innings in six of their last seven games against National League opponents.
  • The Brewers have won the first inning in three of their last four games as favorites against National League opponents.

Why the San Diego Padres will win

  • The underdogs have won five of the Brewers’ last six games.
  • The Brewers have lost three of their last four games as favorites against National League opponents following a road win.
  • The Padres have covered the run line in each of their last six games as underdogs against National League opponents following a loss.
  • The Brewers have failed to cover the run line in each of their last five home games against National League opponents following a win.
  • The Brewers have trailed after 5 innings in four of their last five night games against opponents that held a winning record.
  • The Padres have led after 3 innings in four of their last five night games against the Brewers.
  • The Brewers have lost the first inning in each of their last three home games against NL West opponents.

Milwaukee Brewers Player Prop Facts

  • Christian Yelich has hit a home run in three of his last four appearances with the Brewers as favorites against NL West opponents.
  • Christian Yelich has recorded at least one RBI in each of the Brewers’ last four night games.
  • Christian Yelich has scored at least one run in each of the Brewers’ last seven games as favorites against NL opponents.
  • Sal Frelick has recorded at least one hit in each of his last 18 appearances with the Brewers as favorites against NL opponents.
  • Sal Frelick has recorded at least one Single in each of his last 12 appearances with the Brewers as favorites against NL opponents.

San Diego Padres Player Prop Facts

  • Manny Machado has hit a home run in four of the Padres’ last seven games as underdogs against NL opponents.
  • Manny Machado has recorded at least one RBI in nine of the Padres’ last 10 games as underdogs against NL opponents.
  • Manny Machado has scored at least one run in each of the Padres’ last four road games against NL Central opponents.
  • Jake Cronenworth has recorded at least one hit in each of his last seven appearances in night games against NL Central teams that held a winning record.
  • Jake Cronenworth has recorded at least one Single in each of his last six appearances in night games against NL Central teams that held a winning record.
  • Manny Machado ranks T8th in the league in Hits (72) this season.

Brewers vs Padres Prediction

Vasquez has been a bit shaky in his last couple of starts, allowing 12 hits and seven runs in his last 9.2 innings. Not ideal when going up against a Brewers team that’s quietly been one of the best in baseball over the last couple of weeks. Patrick has also been dealing this season with his 2.97 ERA and 1.21 WHIP, and he has a 2.37 ERA and .221 allowed batting average in 38 home innings. In his last 15.1 innings, Patrick has allowed 12 hits, three runs, and has 19 strikeouts. I’ll lay the reasonable price with the Brewers at home.

Randy Chambers's Free Pick: Milwaukee Brewers -148

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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