Cardinals vs Brewers Prediction 4/25/25 MLB Picks Today

In this article we will formulate a Cardinals vs Brewers prediction for this MLB game on Friday, April 25th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 10-15 this year after they lost two out of three against the Braves by scores of 6-7, 10-4, and 1-4. In their game three loss, the Cardinals led 1-0 in the first inning, but they scored exactly zero runs over the last eight innings for the loss. St. Louis recorded seven hits in the game and they were led by Arenado, who had one RBI in the loss. The Cardinals started Mikolas, who allowed six hits over 6.0 innings, while Romero allowed two earned runs over 0.1 innings for the loss. 

Prior to that series, the Cardinals lost all four against the Mets, but did win two out of three against the Astros before that. St. Louis has lost six of their last seven games and they are currently fourth in the NL Central standings. he St. Louis pitching staff has a 4.37 ERA with a 1.24 WHIP and a .236 opponent batting average, while their offense has scored 120 runs with a .264 batting average and a .335 on base percentage this season. Lars Nootbaar has led St. Louis with four home runs, 14 RBIs, and three stolen bases, while Brendan Donovan has added three home runs and 13 RBIs this year. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 1-2 with a 3.60 ERA and a 1.00 WHIP over 25.0 innings pitched this year. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 13-13 this season after they lost three out of four against the Giants by scores of 2-5, 11-3, 2-4, and 5-6. In their loss on Thursday, the Brewers led 5-2 in the fourth inning, but they allowed the last four runs in the game for the heartbreaking loss. Milwaukee recorded nine hits and they committed one error in the game, while they were led by Frelick, Yelich, and Haase, who all had one RBI in the loss. The Brewers started Myers, who allowed four hits and two earned runs over 4.0 innings, while Alexander picked up the loss in the eighth. 

Prior to that series, the Brewers won two out of three against the Athletics and two out of three against the Tigers. Milwaukee has lost four of their last six games and they are currently second in the NL Central standings. The Milwaukee pitching staff has a 4.23 ERA with a 1.33 WHIP and a .236 opponent batting average, while the offense has scored 132 runs with a .245 batting average and a .320 on base percentage this season. Jackson Chourio has led Milwaukee with five home runs and 20 RBIs, while Christian Yelich has also added five home runs and 20 RBIs this year. The projected starting pitcher for Milwaukee is Chad Patrick, who is 1-1 with a 2.11 ERA and a 1.31 WHIP over 21.1 innings pitched this season. 

Why the Cardinals will beat the Brewers

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Milwaukee Brewers Player Prop Facts

Cardinals vs Brewers Prediction 

St. Louis comes into this series struggling over the last week, but they will be at home, where they are 8-4 on the season. Milwaukee is just 4-9 on the road so far this year and they are coming off of an ugly series in San Francisco. Both of these starting pitchers have been solid to start the 2025 season, but Liberatore has done a very good job of limiting walks + picking up strikeouts. Take the Cardinals to get the win here. 

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