Cardinals vs Guardians Prediction 4/13/26 MLB Picks Today

The Cleveland Guardians and St. Louis Cardinals meet Monday in MLB action at Busch Stadium. Here’s a Cardinals vs. Guardians Prediction. This article will include a Cardinals vs. Guardians Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 9-7 on the year and play the Orioles and Astros next. The Cleveland Guardians are batting. 222 on the season, have a .311 OBP, and have a .370 slugging percentage. The Cleveland Guardians pitching staff has a 4.05 ERA and a 1.28 WHIP. Chase DeLauter leads the Cleveland Guardians with 15 hits and 12 RBI while Steven Kwan and Angel Martinez have combined for 27 hits and 10 RBI.

Gavin Williams gets the ball for the Cleveland Guardians, and he is 1-1 with a 2.04 ERA and 25 strikeouts this season. This will be Williams’ second career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 8-7 on the year and play the Marlins and Astros next. The St. Louis Cardinals are batting .224 on the season and have a .320 OBP, and a .356 slugging percentage. The St. Louis Cardinals pitching staff has a 5.10 ERA and a 1.48 WHIP. Jordan Walker leads the St. Louis Cardinals with 18 hits and 14 RBI while Alec Burleson and JJ Wetherholt have combined for 26 hits and 16 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 0-0 with a 3.38 ERA and 10 strikeouts this season. Liberatore is 1-1 with a 3.09 ERA and 8 strikeouts in his career against the Cleveland Guardians.

Why the St. Louis Cardinals will win

Why the Cleveland Guardians will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Cleveland Guardians Player Prop Facts

Matchup/League Facts

Cardinals vs Guardians Prediction

The Guardians’ pitching staff got rocked in Atlanta and now they have to travel after playing Sunday night. The Cardinals didn’t have to travel yesterday so there’s a rest advantage for the home team. I’d consider the under with the way Williams and Liberatore have looked through a couple of starts, but I’m going to side with the Cardinals if forced to pick a side. The Guardians’ pitching is coming off a rough weekend and now has a tough travel spot. Give me the Cards at home and the cheap price.

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