Cardinals vs Padres Prediction 7/26/25 MLB Picks Today

In this article we will formulate a Cardinals vs Padres prediction for this MLB game on Saturday, July 26th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 54-51 this year after they won the first two games in this series by scores of 9-7 and 3-0. In their game two win, St. Louis scored once in the second and twice in the fourth for the shutout win. The Cardinals recorded five hits and they committed one error in the game, while they were led by Winn, who went 1-2 with two RBIs in the win. St. Louis started Mikolas, who allowed seven hits and zero earned runs over 5.0 innings for the win, while Helsley picked up the save. 


Prior to this series, the Cardinals lost two out of three against the Rockies and all three against the Diamondbacks. St. Louis has won three of their last five games and they are currently fourth in the NL Central standings. The St. Louis pitching staff has a 4.19 ERA with a 1.29 WHIP and a .256 opponent batting average, while their offense has scored 473 runs with a .253 batting average and a .322 on base percentage this season. Wilson Contreras has led St. Louis with 14 home runs, 61 RBIs, and four stolen bases, while Nolan Arenado has added 10 home runs and 43 RBIs this year. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 6-7 with a 4.13 ERA and a 1.25 WHIP over 100.1 innings pitched this year. 

San Diego Padres Betting Preview

The San Diego Padres are 55-49 this season after they lost game two by a score of 3-0 on Friday night. San Diego generated plenty of hits in the game, but couldn’t find any runs in the low scoring loss. The Padres recorded 11 hits in the game and they committed one error, while they were led by Tatis, Machado, and Bogaerts, who all had two hits in the loss. SD started Pivetta, who allowed three hits and two earned runs over 6.1 innings for the loss, while Morgan and Peralta finished the game. 

Prior to this series, the Padres lost two out of three against the Marlins, but did win two out of three against the Nationals. San Diego has lost four games in a row and they are currently second in the NL West standings. The San Diego pitching staff has a 3.62 ERA with a 1.24 WHIP and a .231 opponent batting average, while their offense has scored 414 runs with a .247 batting average and a .314 on base percentage this season. Manny Machado has led San Diego with 19 home runs and 63 RBIs, while Fernando Tatis has added 17 home runs and 43 RBIs this year. The projected starting pitcher for San Diego is Randy Vasquez, who is 3-4 with a 3.73 ERA and a 1.41 WHIP over 99.0 innings pitched this season. 

Why the Padres will beat the Cardinals

Total Runs Facts

St. Louis Cardinals Player Prop Facts

San Diego Padres Player Prop Facts

Cardinals vs Padres Prediction 

St. Louis has bounced back from that series loss to Colorado with two nice wins to start this series, as they try to stay in the wild card race. The Cardinals are 31-20 at home this season, while the Padres are 24-31 on the road. San Diego is trying to snap this losing streak and they will turn to Vasquez, who has allowed two earned runs or fewer in four of his last five starts. The Cardinals are going with Liberatore, who has also allowed two earned runs or fewer in four of his last five, but did allow six earned runs last time out. I think Vasquez has done a great job of giving San Diego a chance to win and I like them with the plus money. 

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