Cardinals vs Phillies Prediction 4/11/25 MLB Picks Today

The Philadelphia Phillies and St. Louis Cardinals meet on Friday in MLB action at Busch Stadium. Here’s a Cardinals vs Phillies Prediction. This article will include a Cardinals vs Phillies Pick.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 8-4 on the year and play the Giants, Marlins, and Mets next. The Philadelphia Phillies are batting .257 on the season, have a .355 OBP, and a .416 slugging percentage. The Philadelphia Phillies’ pitching staff has a 3.50 ERA and a 1.21 WHIP. Kyle Schwarber leads the Philadelphia Phillies with 13 hits and 12 RBI, while Nick Castellanos and Bryce Harper have combined for 24 hits and 12 RBI.

Aaron Nola gets the ball for the Philadelphia Phillies, and he is 0-2 with a 6.35 ERA and 10 strikeouts this season. Nola is 8-3 with a 2.56 ERA and 85 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 5-7 on the year and play the Astros, Mets, and Braves next. The St. Louis Cardinals are batting .278 on the season, have a .351 OBP, and a .437 slugging percentage. The St. Louis Cardinals’ pitching staff has a 5.24 ERA and a 1.31 WHIP. Brendan Donovan leads the St. Louis Cardinals with 18 hits and 10 RBI, while Nolan Arenado and Lars Nootbaar have combined for 26 hits and 12 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 1-0 with a 3.86 ERA and 9 strikeouts this season. Pallante is 0-1 with a 7.45 ERA and 5 strikeouts in his career against the Philadelphia Phillies.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last six games as underdogs against National League opponents following a loss.
• The Phillies have lost six of their last nine games as road favorites after playing the previous day.
• The Cardinals have covered the run line in each of their last seven games as underdogs against National League opponents.
• The Phillies have failed to cover the run line in six of their last eight road games after playing the previous day.
• The Cardinals have won the first inning in three of their last four night games against National League opponents that held a winning record.
• The Cardinals have led after 3 innings in each of their last four night games against NL East opponents that held a winning record.
• The Cardinals have led after 5 innings in six of their last seven games as home underdogs against National League opponents.

Why the Philadelphia Phillies will win

• The Cardinals have lost each of their last 10 Friday home games against NL East opponents.
• The Phillies have won 15 of their last 16 games against the Cardinals following a loss.
• The Phillies have covered the run line in each of their last 10 games against National League opponents after going to extra innings.
• The Cardinals have failed to cover the run line in each of their last four games against NL East opponents.
• The Phillies have led after 3 innings in four of their last five games against NL Central opponents.
• The Phillies have led after 5 innings in eight of their last 10 night games against the Cardinals.

Cardinals vs Phillies Prediction

This line is kind of nuts. Yes, Nola hasn’t been good through a couple of starts this season, but he’s still an all-star caliber pitcher with great stuff, and those struggles won’t last forever. The Phillies are also far and away the more talented team that’s also playing better ball right now. The Cardinals aren’t playing great ball right now, with losses in seven of their last nine games, and Pallante doesn’t have the sample size to get excited about. You can make a strong argument that the Phillies should be larger favorites. Give me the Phillies.