Cardinals vs Rays Prediction 8/22/25 MLB Picks Today

In this article, we will formulate a Cardinals vs Rays Prediction for this MLB game on Friday, August 22nd at the George M. Steinbrenner Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 61-67 record this season and are sitting on the 4th place of the AL East. The Rays have a 32-33 home record and are 54-67 in over/under. They are coming off a 4-7 home defeat by the Cardinals, and have four consecutive losses. Over is 8-2 in their last 10 games and are playing the Guardians and the Nationals next.

The Rays have a .250 batting average this season, .313 OBP and .306 slugging percentage. Tampa’s pitching staff has a 4.01 ERA and 1.22 WHIP.  Yandy Diaz leads the Rays with 135 hits, while Jonathan Aranda is the team’s best hitter with .316 batting average. Junior Caminero leads the team in RBI, with 86 and in home runs, with 35.

Adrian Houser (R) is the projected starting pitcher for the Rays, and he has a 6-4 record, 2.67 ERA and 1.29 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 64-65 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 29-35 road record and are 65-57 in over/under They are coming off a 7-4 road victory over the Rays, and are 3-1 in their last 4 games. Over is 5-0-1 in their last 6 games and are playing the Pirates and the Reds next.

The Cardinals have a .250 batting average this season, .318 OBP and .386 Slugging percentage. Saint Louis’ pitching staff has a 4.25 ERA and 1.30 WHIP. Brendan Donovan leads the Cardinals with 118 hits, while Alec Burleson is the team’s best hitter with a .285 batting average. Wilson Contreras leads the team in RBI, with 68, adding a team-high 18 home runs.

Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has a 6-9 record, 4.99 ERA and 1.30 WHIP.

Why the Tampa Bay Rays will win

Why the St. Louis Cardinals will win

Total Runs Facts

Matchup/League Facts

Cardinals vs Rays Prediction

The Cardinals are 5-1 in their last 6 meetings against the Rays, and have won their last three visits in Tampa Bay. Under is 5-3 in their last 8 meetings.

In this Cardinals vs Rays Prediction, the Rays are coming as -140 home favorites. I’m om the Rays in this one, as House has been amazing at home, with a 1.38 home ERA, and he is coming off a shutout start against the Giants. On the flip side, Mikolas has been weaker on the road with a 6.47 road ERA, and he is up against a Rays offense that is much more efficient against right-handed pitching. Take the Tampa Bay Rays to get the job done at home in this one.

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