Cardinals vs Reds Prediction 6/21/25 MLB Picks Today

The Cincinnati Reds and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Cardinals vs Reds Prediction. This article will include a Cardinals vs Reds Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 39-37 on the year and play the Yankees, Padres, and Red Sox next. The Cincinnati Reds are batting .247 on the season, have a .321 OBP, and a .401 slugging percentage. The Cincinnati Reds pitching staff has a 3.90 ERA and a 1.23 WHIP. TJ Friedl leads the Cincinnati Reds with 80 hits and 29 RBI, while Elly De La Cruz and Gavin Lux have combined for 136 hits and 81 RBI.

Brent Suter gets the ball for the Cincinnati Reds, and he is 1-0 with a 2.91 ERA and 21 strikeouts this season. Suter is 2-2 with a 3.34 ERA and 54 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 41-35 on the year and play the Cubs, Guardians, and Pirates next. The St. Louis Cardinals are batting .257 on the season, have a .329 OBP, and a .395 slugging percentage. The St. Louis Cardinals’ pitching staff has a 3.94 ERA and a 1.27 WHIP. Brendan Donovan leads the St. Louis Cardinals with 83 hits and 27 RBI, while Alec Burleson and Willson Contreras have combined for 133 hits and 77 RBI.

Sonny Gray gets the ball for the St. Louis Cardinals, and he is 7-2 with a 3.84 ERA and 85 strikeouts this season. Gray is 1-3 with a 4.70 ERA and 28 strikeouts in his career against the Cincinnati Reds.

Why the St. Louis Cardinals will win

Why the Cincinnati Reds will win

St. Louis Cardinals Player Prop Facts

Cincinnati Reds Player Prop Facts

Cardinals vs Reds Prediction

Not a fan of bullpen games, and Suter hasn’t pitched well this month, allowing eight hits and three runs in his last 5.2 innings. The Reds are rolling this week, and Gray has been fabulous this season with a 3.84 ERA and 1.18 WHIP. In 53.2 home innings, Gray has a 2.85 ERA and .245 allowed batting average with 57 strikeouts. The Reds are in good form right now, and there’s a head-and-shoulders edge on the mound. I’ll side with the Reds and take the RL to shave down the price.

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